cas 175278-07-6, 2-(Trifluoromethoxy)benzyl alcohol

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RORγ MODULATORS
The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.
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Page/Page column 21; 38; 66

(2018/04/13)

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists
The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.
Doebelin, Christelle,Patouret, Rémi,Garcia-Ordonez, Ruben D.,Chang, Mi Ra,Dharmarajan, Venkatasubramanian,Kuruvilla, Dana S.,Novick, Scott J.,Lin, Li,Cameron, Michael D.,Griffin, Patrick R.,Kamenecka, Theodore M.
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p. 2607 - 2620
(2016/12/09)

Tocolytic oxytocin receptor antagonists
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
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(2008/06/13)

PIPERAZINE OXYTOCIN RECEPTOR ANTAGONISTS
This invention relates to certain novel piperazine compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.
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(2008/06/13)

Chemical Properties

Boiling Point: 190.7 °C at 760 mmHg
Flash Point:96.5 °C
Density: 1.337 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 0.337mmHg at 25°C
Refractive Index: 1.466
PKA: 14.12±0.10(Predicted)
PSA: 29.46000
LogP: 2.07750

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Chemical Properties

Boiling Point: 190.7 °C at 760 mmHg

Flash Point:96.5 °C

Density: 1.337 g/cm³

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 0.337mmHg at 25°C

Refractive Index: 1.466

PKA: 14.12±0.10(Predicted)

PSA: 29.46000

LogP: 2.07750

Global suppliers and manufacturers of 175278-07-6total 51 suppliers on LookChem

Article Database

175278-07-6

Articles about 175278-07-6Total 4 be found

More Articles about upstream products of 175278-07-6

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Chemical Properties

Boiling Point: 190.7 °C at 760 mmHg

Flash Point:96.5 °C

Density: 1.337 g/cm3

Storage Temp.:Sealed in dry,Room Temperature

Vapor Pressure: 0.337mmHg at 25°C

Refractive Index: 1.466

PKA: 14.12±0.10(Predicted)

PSA: 29.46000

LogP: 2.07750

Global suppliers and manufacturers of 175278-07-6total 51 suppliers on LookChem

Density: 1.337 g/cm³