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(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid is a chemical compound belonging to the class of substituted imidazoles. It is characterized by its off-white solid appearance and is known for its inhibitory properties towards trypsin-like activity of factor XIa (TAFIa), which plays a significant role in the regulation of coagulation and fibrinolysis processes in the body.

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  • 17561-26-1 Structure
  • Basic information

    1. Product Name: (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid
    2. Synonyms: (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid;(S)-a-Chloro-1H-imidazole-4-propanoic Acid;NSC 30490;((S)-Chloro-1H-imidazole-4-propanoic Acid;NSC 304903)
    3. CAS NO:17561-26-1
    4. Molecular Formula: C6H7ClN2O2
    5. Molecular Weight: 174.586
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Heterocycles;Inhibitors
    8. Mol File: 17561-26-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 451.2°Cat760mmHg
    3. Flash Point: 226.7°C
    4. Appearance: /
    5. Density: 1.496g/cm3
    6. Refractive Index: 1.589
    7. Storage Temp.: -20°C Freezer
    8. Solubility: DMSO (Slightly), Water (Sparingly)
    9. CAS DataBase Reference: (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid(17561-26-1)
    11. EPA Substance Registry System: (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid(17561-26-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 17561-26-1(Hazardous Substances Data)

17561-26-1 Usage

Uses

Used in Pharmaceutical Industry:
(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid is used as a TAFIa inhibitor for its potential application in the development of therapeutic agents targeting coagulation and fibrinolysis-related disorders. By inhibiting TAFIa, this compound may help in the treatment of conditions such as thrombosis, deep vein thrombosis, and other clot-related diseases.
Additionally, due to its chemical properties and structure, (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid may also find applications in other industries, such as:
Used in Chemical Synthesis Industry:
(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid can be used as a building block or intermediate in the synthesis of more complex molecules, potentially leading to the development of new drugs or materials with various applications.
Used in Research and Development:
As a substituted imidazole, (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid may be utilized in academic and industrial research settings to study its properties, interactions, and potential applications in various fields, including medicinal chemistry, materials science, and biotechnology.

Check Digit Verification of cas no

The CAS Registry Mumber 17561-26-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,5,6 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 17561-26:
(7*1)+(6*7)+(5*5)+(4*6)+(3*1)+(2*2)+(1*6)=111
111 % 10 = 1
So 17561-26-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H7ClN2O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1H2,(H,8,9)(H,10,11)/t5-/m0/s1

17561-26-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid

1.2 Other means of identification

Product number -
Other names (2S)-2-chloro-3-(1H-imidazol-5-yl)propanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17561-26-1 SDS

17561-26-1Relevant articles and documents

Histidine derivatives as tridentate chelators for the fac-[M I(CO)3] (Re, 99mTc, 188Re) core: Synthesis, structural characterization, radiochemistry and stability

Papagiannopoulou, Dionysia,Tsoukalas, Charalambos,Makris, George,Raptopoulou, Catherine P.,Psycharis, Vassilis,Leondiadis, Leondios,Gdniazdowska, Ewa,Kozminski, Przemyslaw,Fuks, Leon,Pelecanou, Maria,Pirmettis, Ioannis,Papadopoulos, Minas S.

, p. 333 - 337 (2011)

The development of new rhenium(I)- and technetium(I)-tricarbonyl complexes can lead to potentially useful radiopharmaceuticals. In this work, the synthesis of the neutral rhenium complex fac-[Re(NSO)(CO)3], Re-1, where NSO is the tridentate che

Efficient preparation of urocanic acid derivatives from histidine

Lovely, Carl J.,Sivappa, Rasapalli,Mukherjee, Sabuj,Doundoulakis, Thomas,Lima, Heather M.,Yousufuddin, Muhammed

scheme or table, p. 1353 - 1358 (2010/10/20)

Urocanic acid derivatives have served as useful starting materials in several total synthesis endeavors in our lab. This paper describes a convenient, large-scale synthesis of several derivatives of urocanic acid via the net elimination of ammonia from hi

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