175614-03-6Relevant articles and documents
Sequence-specific DNA alkylation by hybrid molecules between segment A of duocarmycin A and pyrrole/imidazole diamide
Tao, Zhi-Fu,Fujiwara, Tsuyoshi,Saito, Isao,Sugiyama, Hiroshi
, p. 650 - 653 (2007/10/03)
In the absence of distamycin A (Dist), hybrids 1 (X = N, CH) selectively alkylate the 3' end of adenine in AT-rich DNA sequences. However, these hybrids can form a heterodimer with Dist to alkylate G residues of predetermined DNA sequences efficiently and with high selectivity.