- Total Synthesis of (?)-Pepluanol B: Conformational Control of the Eight-Membered-Ring System
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The first total synthesis of the Euphorbia diterpenoid pepluanol B in both racemic and enantioenriched form involves 20 steps from a known bicyclic diol. This synthesis features an unprecedented bromo-epoxidation to control the eight-membered-ring conform
- Chen, Peiqi,Fang, Ran,Li, Huilin,Liu, Meng,She, Xuegong,Wu, Chuanhua,Xie, Xingang,Zhang, Jing,Zhao, Gaoyuan,Zhou, Lin
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supporting information
p. 3966 - 3970
(2020/02/05)
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- Bicycro [3.3.0] octane -2,6-diyl compd. having, a liquid crystal display element and a liquid crystal composition
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A liquid crystal compound having a high stability to heat, light or the like, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy, a suitable
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Paragraph 0125; 0126
(2016/10/07)
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- NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
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The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), (II-ii), (II-iii), and (II-iv). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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Page/Page column 61-62
(2016/06/28)
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- NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES
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The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes (I); wherein A is -C(R1)= or -N=; and X is selected from the group consisting of: (II-i), and (II-ii). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
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Page/Page column 62; 63
(2016/06/28)
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- Total synthesis and NMR investigations of cylindramide
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Cylindramide (1) was built up from three components: a hydroxyornithine derivative 7, a tetrazolylsulfone 8, and a substituted pentalene subunit 9. Derivative 7 was prepared in a six-step reaction sequence involving the Wittig reaction and a Sharpless asy
- Cramer, Nicolai,Buchweitz, Maria,Laschat, Sabine,Frey, Wolfgang,Baro, Angelika,Mathieu, Daniel,Richter, Christian,Schwalbe, Harald
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p. 2488 - 2503
(2008/02/03)
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- Synthesis of (R,R) and (S,S) bicyclo[3.3.0]octane-2,6-dione interactions between non-conjugated chromophores
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Optically pure bicylo[3.3.0]octane-2,6-dione is easily obtained with a yield of 4 % for each enantiomer from 1,5-cyclooctadiene in 5 steps, by resolution of the intermediate diol with menthyloxyacetic acid. Its CD is 60 % larger than twice the CD of a corresponding monoketone indicating interactions between non-conjugated chromophores.
- Perard-Viret,Rassat
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- SYNTHESIS OF A PROSTAGLANDIN SYNTHON - endo-cis-BICYCLOOCT-6-EN-2-OL - FROM Z,Z-1,5-CYCLOOCTADIENE
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A method was developed for the synthesis of the prostaglandin synthon endo-cis-bicyclooct-6-en-2-ol from Z,Z-1,5-cyclooctadiene in three stages.The conditions for the synthesis of 6-exo-chloro-2-endo-acetoxy-cis-bicyclooctane from the same diene were determined.
- Chernyuk, K. Yu.,Mel'nikova, V. I.,Pivnitskii, K. K.
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p. 503 - 507
(2007/10/02)
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