17573-84-1Relevant articles and documents
A NEW ROUTE TO THE SYNTHESIS OF 5-FLUOROURACIL
Baasner, B.,Klauke, E.
, p. 417 - 430 (2007/10/02)
Starting from tetrafluoropyrimidine (1), selective fluorine/chlorine exchange reactions and selective hydrogenolysis of the chlorine substituents are described.Combination of these methods, together with a subsequent hydrolysis reaction, provides a new route to the synthesis of 5-fluorouracil via 4,6-dichloro-2,5-difluoropyrimidine and 4-chloro-2,5-difluoropyrimidine.
Process for the selective hydrogenation of chlorine-containing pyrimidines and new pyrimidines
-
, (2008/06/13)
Chlorine-containing pyrimidines are selectively hydrogenated with elimination of hydrogen chloride, without other substituents and/or the aromatic ring being significantly attacked, by using a hydrogenation catalyst and a hydrogen chloride acceptor. This process gives predominantly new pyrimidines.