- Synthesis, Purification, and Selective β2-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from Portulaca oleracea
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A green, biomimetic, phosphate-mediated Pictet-Spengler reaction was used in the synthesis of three catecholic tetrahydroisoquinolines, 1, 2, and 12, present in the medicinal plant Portulaca oleracea, as well as their analogues 3-11, 13, and 14, with dopa
- Yang, Er-Lan,Sun, Bin,Huang, Zi-Yi,Lin, Jian-Guang,Jiao, Bo,Xiang, Lan
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p. 2986 - 2993
(2019/11/03)
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- Phosphate mediated biomimetic synthesis of tetrahydroisoquinoline alkaloids
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A one-pot synthesis of tetrahydroisoquinoline alkaloids in a phosphate buffer has been achieved, and a reaction mechanism proposed. The utilisation of mild reaction conditions readily afforded a range of isoquinolines, including norcoclaurine.
- Pesnot, Thomas,Gershater, Markus C.,Ward, John M.,Hailes, Helen C.
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supporting information; experimental part
p. 3242 - 3244
(2011/05/05)
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- 1-Aryl-tetrahydroisoquinoline analogs as active anti-HIV agents in vitro
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A series of 1-aryl-6,7-dihydroxyl(methoxy)-1,2,3,4-tetrahydroisoquinolines (compounds 1-36) were synthesized via Pictet-Spengler cyclization. All the synthesized compounds were assayed for activities against HIV-1IIIB in C8166 cell cultures by
- Cheng, Pi,Huang, Ning,Jiang, Zhi-Yong,Zhang, Quan,Zheng, Yong-Tang,Chen, Ji-Jun,Zhang, Xue-Mei,Ma, Yun-Bao
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p. 2475 - 2478
(2008/09/20)
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