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Pyridine, 2-fluoro-4-methoxy(9CI) is a pyridine derivative characterized by a pyridine ring with a fluorine atom and a methoxy group attached at the 2 and 4 positions, respectively. It is a valuable chemical compound used in various fields, including organic chemistry, pharmaceutical research, materials science, and industrial processes.

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  • 175965-83-0 Structure
  • Basic information

    1. Product Name: Pyridine, 2-fluoro-4-methoxy- (9CI)
    2. Synonyms: Pyridine, 2-fluoro-4-methoxy- (9CI);2-Fluoro-4-methoxypyridine
    3. CAS NO:175965-83-0
    4. Molecular Formula: C6H6FNO
    5. Molecular Weight: 127.1163432
    6. EINECS: N/A
    7. Product Categories: PYRIDINE
    8. Mol File: 175965-83-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 166.6ºC at 760 mmHg
    3. Flash Point: 54.6ºC
    4. Appearance: /
    5. Density: 1.146
    6. Vapor Pressure: 2.33mmHg at 25°C
    7. Refractive Index: 1.471
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: Pyridine, 2-fluoro-4-methoxy- (9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Pyridine, 2-fluoro-4-methoxy- (9CI)(175965-83-0)
    12. EPA Substance Registry System: Pyridine, 2-fluoro-4-methoxy- (9CI)(175965-83-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 175965-83-0(Hazardous Substances Data)

175965-83-0 Usage

Uses

Used in Organic Chemistry:
Pyridine, 2-fluoro-4-methoxy(9CI) is used as a building block for the synthesis of various biologically active compounds due to its unique structure and functional groups.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Pyridine, 2-fluoro-4-methoxy(9CI) serves as an intermediate in the development of drugs and agrochemicals, contributing to the creation of novel therapeutic agents.
Used in Materials Science:
Pyridine, 2-fluoro-4-methoxy(9CI) may have potential applications in materials science, where its specific properties can be utilized to develop new materials with desired characteristics.
Used in Industrial Processes:
Additionally, Pyridine, 2-fluoro-4-methoxy(9CI) may be employed in various industrial processes, where its chemical properties can be leveraged for specific applications and improvements in product development.

Check Digit Verification of cas no

The CAS Registry Mumber 175965-83-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,9,6 and 5 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175965-83:
(8*1)+(7*7)+(6*5)+(5*9)+(4*6)+(3*5)+(2*8)+(1*3)=190
190 % 10 = 0
So 175965-83-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H6FNO/c1-9-5-2-3-8-6(7)4-5/h2-4H,1H3

175965-83-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Fluoro-4-methoxypyridine

1.2 Other means of identification

Product number -
Other names PYRIDINE,2-FLUORO-4-METHOXY

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175965-83-0 SDS

175965-83-0Relevant articles and documents

PhenoFluorMix: Practical chemoselective deoxyfluorination of phenols

Fujimoto, Teppei,Ritter, Tobias

supporting information, p. 544 - 547 (2015/03/05)

A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.

C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE

-

Paragraph 00123, (2015/02/19)

The present invention provides compositions and methods for the selective C-H fluorination of nitrogen-containing heteroarenes with AgF2, which has previously been considered too reactive for practical, selective C-H fluorination. Fluorinated heteroarenes are prevalent in numerous pharmaceuticals, agrochemicals and materials. However, the reactions used to introduce fluorine into these molecules require pre-functionalized substrates or the use of F2 gas. The present invention provides a mild and general method for the C-H fluorination of nitrogen-containing heteroarene compounds to 2-fluoro-heteroarenes with commercially available AgF2. In various embodiments, these reactions occur at ambient temperature within one hour and occur with exclusive selectivity for fluorination at the 2-position. Exemplary reaction conditions are effective for fluorinating diazine heteroarenes to form a single fluorinated isomer.

Selective C-H fluorination of pyridines and diazines inspired by a classic amination reaction

Fier, Patrick S.,Hartwig, John F.

, p. 956 - 960 (2013/12/04)

Fluorinated heterocycles are prevalent in pharmaceuticals, agrochemicals, and materials. However, reactions that incorporate fluorine into heteroarenes are limited in scope and can be hazardous. We present a broadly applicable and safe method for the site-selective fluorination of a single carbon-hydrogen bond in pyridines and diazines using commercially available silver(II) fluoride. The reactions occur at ambient temperature within 1 hour with exclusive selectivity for fluorination adjacent to nitrogen. The mild conditions allow access to fluorinated derivatives of medicinally important compounds, as well as a range of 2-substituted pyridines prepared by subsequent nucleophilic displacement of fluoride. Mechanistic studies demonstrate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a broad range of nitrogen heterocycles.

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