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176032-72-7

3-(3-QUINOLINYL)ANILINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 176032-72-7 Structure

  • Basic information

    1. Product Name: 3-(3-QUINOLINYL)ANILINE
    2. Synonyms: AKOS BAR-0439;3-QUINOLIN-3-YL-PHENYLAMINE;3-(3-QUINOLINYL)ANILINE
    3. CAS NO:176032-72-7
    4. Molecular Formula: C15H12N2
    5. Molecular Weight: 220.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 176032-72-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(3-QUINOLINYL)ANILINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(3-QUINOLINYL)ANILINE(176032-72-7)
    11. EPA Substance Registry System: 3-(3-QUINOLINYL)ANILINE(176032-72-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 176032-72-7(Hazardous Substances Data)

176032-72-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 176032-72-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,0,3 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 176032-72:
(8*1)+(7*7)+(6*6)+(5*0)+(4*3)+(3*2)+(2*7)+(1*2)=127
127 % 10 = 7
So 176032-72-7 is a valid CAS Registry Number.

176032-72-7Downstream Products

176032-72-7Relevant articles and documents

DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS

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Paragraph 69; 126; 150, (2018/12/02)

The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution

Nguyen, Thuy,German, Nadezhda,Decker, Ann M.,Langston, Tiffany L.,Gamage, Thomas F.,Farquhar, Charlotte E.,Li, Jun-Xu,Wiley, Jenny L.,Thomas, Brian F.,Zhang, Yanan

, p. 7410 - 7424 (2017/09/22)

Allosteric modulators of the cannabinoid CB1 receptor have recently been reported as an alternative approach to modulate the CB1 receptor for therapeutic benefits. In this study, we report the design and synthesis of a series of diarylureas derived from PSNCBAM-1 (2). Similar to 2, these diarylureas dose-dependently inhibited CP55,940-induced intracellular calcium mobilization and [35S]GTP-γ-S binding while enhancing [3H]CP55,940 binding to the CB1 receptor. Structure-activity relationship studies revealed that the pyridinyl ring of 2 could be replaced by other aromatic rings and the pyrrolidinyl ring is not required for CB1 allosteric modulation. 34 (RTICBM-74) had similar potencies as 2 in all in vitro assays but showed significantly improved metabolic stability to rat liver microsomes. More importantly, 34 was more effective than 2 in attenuating the reinstatement of extinguished cocaine-seeking behavior in rats, demonstrating the potential of this diarylurea series as promising candidates for the development of relapse treatment of cocaine addiction.

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