cas 176045-80-0, 1-(4-Bromobenzyl)-1-(4-methoxyphenyl)hydrazine | Articles data ｜lookchem

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176045-80-0

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COMPOSITIONS AND TREATMENTS COMPRISING 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS AND NITRIC OXIDE MODULATORS
Disclosed herein are compositions and compounds that combine an inhibitor of 5-lipoxygenase activating protein (FLAP) and a modulator of NO levels in a mammal. The NO modulator can be an agent that induces the production of NO in a mammal, or can be an ag
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Page/Page column 95-96

(2008/12/06)

From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2-inhibitors
A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidence of GI toxicity, even at high doses.
Black,Bayly,Belley,Chan,Charleson,Denis,Gauthier,Gordon,Guay,Kargman,Lau,Leblanc,Mancini,Ouellet,Percival,Roy,Skorey,Tagari,Vickers,et al.
p. 725 - 730
(2007/10/03)

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Chemical Properties

Boiling Point: 445 °C at 760 mmHg
Flash Point:222.9 °C
Density: 1.425 g/cm³
Vapor Pressure: 4.09E-08mmHg at 25°C
Refractive Index: 1.647
PSA: 38.49000
LogP: 4.03830

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