HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS
Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
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Paragraph 0688
(2018/06/12)
A NEW VAPOR-PHASE SYNTHESIS OF THIAZOLES
The vapor-phase reaction of imines with sulfur dioxide to produce thiazoles has been studied at 450 - 500 deg C.Of the imines investigated acetone methyl imine was the most studied which produced 4-methylthiazole in 70percent yield.
Amato, Joseph S.,Karady, Sandor,Phillips, Brian T.,Weinstock, Leonard M.
p. 1947 - 1949
(2007/10/02)
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