- Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides
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An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.
- Bai, Jianfei,Zambron, Bartosz K.,Vogel, Pierre
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supporting information
p. 604 - 607
(2014/04/03)
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- Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed hydrogenation of γ-Ketoamides
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A0series of γ-hydroxy amides were synthesized with high ena~tioselectivities (up to 99%) usyng asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of natu
- Zhao, Mengmeng,Li, Wanfang,Li, Xiaoming,Ren, Kai,Tao, Xiaoming,Xie, Xiaomin,Ayad, Tahar,Ratovelomanana-Vidal, Virginie,Zhang, Zhaowuo
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p. 6164 - 6171
(2014/07/21)
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- Efficient synthesis of 2-aminothiazole-4-phenyl-5-acetamides via the open chain tautomers of γ-keto amides
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A simple and efficient method is described for the synthesis of new functionalized 2-aminothiazoles, the 2-aminothiazole-4-phenyl-5-acetamides 5, in 67-96% yields based on an application of the Hantzsch synthesis. The method involves the reaction of thiou
- Tsolomiti, Georgia,Tsolomitis, Athanase
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p. 501 - 507
(2007/10/03)
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- BEHAVIOUR OF N-ARYLSUCCINISOIMIDIUM PERCHLORATES TOWARDS FRIEDEL-CRAFTS AND GRINGNARD REACTIONS
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N-Arylsuccinisoimidium perchlorates (1a and b) reacted with aromatic hydrocarbons under Friedel-Crafts conditions to give β-aroyl-N-arylpriopionamides (3a-i).The reaction of phenylmagnesium bromide with 1a and 1b proceeded via ring-opening to give 3a and
- Ismail, Mohamed Fekry,Enayat, Ebtesam Ismail,El Bassiouny, Fakhry Abdel Aziz,Younes, Hamed Ahmed
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p. 103 - 108
(2007/10/02)
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- 3,3'-(Phenylphosphinylidene)bis and 3,3'-(Phenylphosphinylidene)bis. New Activating Agents
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New activating agents, 3,3'-(phenylphophinylidene)bis (4) and 3,3'-(phenylphosphinylidene)bis (5), were readily prepared by the reaction of phenylphosphonic dichloride (3) with 2(3H)-benzoxazolone (1) and 2(3H)-benzothiazolone (2) respectively in the presence of triethylamine at room temperature.The new activating agents 4 and 5 were found to be useful for the preparation of amides, esters, and dipeptides under mild conditions.Furthemore, the direct polycondensation of isophthalic acid with aromatic diamines using the activating agent 4 in the presence of pyridine proceeded fast at room temperature to produce polyamides with inherent viscosities up to 0.80 dL/g.
- Ueda, Mitsuru,Mochizuki, Amane,Hiratsuka, Ichiro,Oikawa, Hideaki
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p. 3291 - 3297
(2007/10/02)
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