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Methyl5-(4-chlorophenyl)isoxzole-3-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 176593-36-5 Structure
  • Basic information

    1. Product Name: Methyl5-(4-chlorophenyl)isoxzole-3-carboxylate
    2. Synonyms: Methyl5-(4-chlorophenyl)isoxzole-3-carboxylate;methyl 5-(4-chlorophenyl)-1,2-oxazole-3-carboxylate
    3. CAS NO:176593-36-5
    4. Molecular Formula: C11H8ClNO3
    5. Molecular Weight: 237.63912
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 176593-36-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 396.3°C at 760 mmHg
    3. Flash Point: 193.5°C
    4. Appearance: /
    5. Density: 1.315g/cm3
    6. Vapor Pressure: 1.72E-06mmHg at 25°C
    7. Refractive Index: 1.554
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: Methyl5-(4-chlorophenyl)isoxzole-3-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: Methyl5-(4-chlorophenyl)isoxzole-3-carboxylate(176593-36-5)
    12. EPA Substance Registry System: Methyl5-(4-chlorophenyl)isoxzole-3-carboxylate(176593-36-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 176593-36-5(Hazardous Substances Data)

176593-36-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 176593-36-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,6,5,9 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 176593-36:
(8*1)+(7*7)+(6*6)+(5*5)+(4*9)+(3*3)+(2*3)+(1*6)=175
175 % 10 = 5
So 176593-36-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H8ClNO3/c1-15-11(14)9-6-10(16-13-9)7-2-4-8(12)5-3-7/h2-6H,1H3

176593-36-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 5-(4-chlorophenyl)-1,2-oxazole-3-carboxylate

1.2 Other means of identification

Product number -
Other names HMS1556B17

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:176593-36-5 SDS

176593-36-5Downstream Products

176593-36-5Relevant articles and documents

Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies

Ye, Jiqing,Yang, Xiao,Xu, Min,Chan, Paul Kay-sheung,Ma, Cong

, (2019/09/06)

The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing the 150-cavity which is nascent to the activity site of NA. NA inhibitory studies showed that new derivatives demonstrated the inhibitory activity with IC50 values at nM level against NA of a clinical influenza virus strain. Moreover, the in silico ADME predictions showed that the selected compounds had comparable properties with oseltamivir carboxylate, which demonstrated the druggablity of these derivatives. Furthermore, molecular docking studies showed that the most potent compound 6f and 10i could adopt different modes of binding interaction with NA, which may provide novel solutions for treating oseltamivir-resistant influenza. Based on the research results, we consider that compounds 6f and 10i have the potential for further studies as novel antiviral agents.

Design, synthesis and bioactivities of novel isoxazole-containing pyrazole oxime derivatives

Dai, Hong,Yao, Wei,Fang, Yuan,Sun, Siyu,Shi, Yujun,Chen, Jia,Jiang, Guoqing,Shi, Jian

, (2017/12/05)

In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively.

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