176637-10-8

Basic information

• Product Name: 8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine
• Synonyms: 8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine;4-Chloro-6-(methylthio)pyrimido[5,4-d]pyrimidine;8-chloro-2-(Methylsulfanyl)-[1,3]diazino[5,4-d]pyriMidine
• CAS NO: 176637-10-8
• Molecular Formula: C₇H₅ClN₄S
• Molecular Weight: 212.663
• Mol File: 176637-10-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine(176637-10-8)
• EPA Substance Registry System: 8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine(176637-10-8)

Safety Data

• Hazardous Substances Data: 176637-10-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure may exhibit biological activity, making it a promising candidate for the development of new drugs.
Used in Medicinal Chemistry:
8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine is used as a building block in the design and synthesis of novel therapeutic agents. Its chemical properties can be further modified to create derivatives with improved pharmacological properties, such as increased potency, selectivity, and bioavailability.
Used in Chemical Synthesis:
8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine is used as a key intermediate in the synthesis of complex organic molecules, including natural products, pharmaceuticals, and agrochemicals. Its versatile structure allows for various chemical reactions, enabling the formation of a wide range of compounds with diverse applications.
Used in Biochemical Research:
8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine can be employed as a research tool in biochemical studies, such as enzyme inhibition assays, receptor binding studies, and molecular docking simulations. Its unique structure may provide insights into the mechanisms of biological processes and help identify potential drug targets.
Used in Material Science:
8-Chloro-2-(methylthio)pyrimido[5,4-d]pyrimidine may have potential applications in the development of new materials with specific properties, such as optoelectronic devices, sensors, and catalysts. Its chemical structure can be tailored to achieve desired characteristics, making it a valuable component in material science research.

Upstream product

• 98550-19-7 4-hydroxy-6-methylthio-pyrimido[5,4-d]pyrimidine 

Downstream Products

• 1213249-80-9 C₁₆H₁₅N₅O₂S 
• 1213249-88-7 C₁₅H₁₃N₅O₂S 
• 1213249-79-6 C₂₃H₁₉F₃N₆O₂S 
• 1213250-28-2 C₂₇H₃₁N₇O₄S₂ 
• 1391916-05-4 C₁₆H₁₆F₂N₆O₂S₂ 
• 177908-24-6 4-[(3-Chloro-4-fluoro-phenyl)amino]-6-methylthio-pyrimido[5,4-d]pyrimidine 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS

The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, X1, X1, X3, L1 and L2 are defined as in claim 1, which are suitable for the treatm

Pyrimido [5, 4-d] pyrimidines, pharmaceuticals containing these compounds, their use and processes for their preparation

Pyrimido[5,4-d]pyrimidines of the general formula [Figure] which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of oncoses, and their preparation. Exemplary compounds are: (a) 4-(5-indolylamino)-6-morpholinopyrimido[5,4-d]pyrimidine; (b) 4-(5-indolylamino)-6-[trans-(4-hydroxycyclohexyl)amino]pyrimido[5,4-d]pyrimidine; (c) 4-[(3-chloro-4-fluorophenyl)amino]-6-[4-(morpholinocarbonylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidine; (d) 4-[(3-chloro-4-fluorophenyl)amino]-6-[(4-morpholinyl)amino]pyrimido[5,4-d]pyrimidine; (e) 4-[(3-chloro-4-fluorophenyl)amino]-6-(4-picolylamino)pyrimido[5,4-d]pyrimidine; (f) 4-[(3-chloro-4-fluorophenyl)amino]-6-[1-trifluoroacetyl-4-piperidinylamino]pyrimido[5,4-d]pyrimidine; (g) 4-[(3-chloro-4-fluorophenyl)amino]-6-(endo-tropinylamino)pyrimido[5,4-d]pyrimidine; and, (h) 4-[(3-chloro-4-fluorophenyl)amino]-6-(exo-tropinylamino)pyrimido[5,4-d]pyrimidine.

Pyrimido?5,4-D!pyrimidines, medicaments comprising these compounds, their use and processes for their preparation

The present invention relates to pyrimido?5,4-d!pyrimidines of the general formula STR1 in which Ra to Rc are as defined herein, their tautomers, their stereoisomers and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibiting action on signal transduction mediated by tyrosine kinases, their use for the treatment of diseases, in particular tumor diseases.

Pyrimido[5,4]-dipyrimidines, pharmaceuticals containing them, their use and processes for the preparation thereof

Pyrimido[5,4-d]pyrimidines of the general formula [Figure] which have an inhibitory effect on signal transduction mediated by tyrosine kinases, their use for the treatment of disorders, in particular of oncoses, and their preparation. Exemplary compounds are: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[1-methyl-4-piperidinylamino]pyrimido[5,4-d]pyrimidine, and 4-[(3-Chloro-4-fluorophenyl)amino]-6-[trans-4-dimethyl-aminocycohexylamino]pyrimido[5,4-d]pyrimidine.