Isoquinolmone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
The synthesis of a series of 1-(aryloxy)-3-[[(amido)alkyl]amino]propan-2-ols where either the aryl moiety is heterocyclic or the amidic group is substituted by a heterocyclic moiety is described. Several of the compounds were more potent that propranolol
Large,Smith
p. 1417 - 1422
(2007/10/02)
Synthesis of amide deriatives of morpholine and homomorpholine (hexahydrooxazepine-1,4) with potential pharmacological action
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Kotelko,Glinka
p. 135 - 143
(2007/10/04)
Syntheses of aminoalkylguanidine derivatives.
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Tsuji,Momona,Ueda
p. 936 - 943
(2007/10/04)
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