5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
A series of 5-phenyl-substituted-N-alkyl-imidazolin-2-ones with potent radical-scavenging activity and lipid peroxidation inhibitory activity was synthesized. Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation.
Disclosed are pyrazole derivatives of formula I: Where R1, R2, R3, and R4are defined as in the specification described. These compounds are antagonists of the brain cannabinoid (CB-1) receptors and could be used
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(2008/06/13)
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