17720-99-9

Basic information

• Product Name: thiazol-4-amine
• Synonyms: thiazol-4-amine;4-Thiazolamine;4-Aminothiazole;1,3-thiazol-4-aMine;4-ThiazolaMine HCl
• CAS NO: 17720-99-9
• Molecular Formula: C₃H₄N₂S
• Molecular Weight: 100.14
• Mol File: 17720-99-9.mol

Chemical Properties

• Boiling Point: 239.313 °C at 760 mmHg
• Flash Point: 98.533 °C
• Appearance: /
• Density: 1.345
• Vapor Pressure: 0.04mmHg at 25°C
• Refractive Index: 1.645
• PKA: 3.21±0.10(Predicted)
• CAS DataBase Reference: thiazol-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: thiazol-4-amine(17720-99-9)
• EPA Substance Registry System: thiazol-4-amine(17720-99-9)

Safety Data

• Hazardous Substances Data: 17720-99-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thiazol-4-amine is used as a key intermediate in the synthesis of various pharmaceuticals for the treatment of different diseases. Its unique structure allows for the development of drugs with specific therapeutic properties, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, thiazol-4-amine is utilized as a precursor in the production of pesticides and other agrochemicals. Its chemical properties enable the creation of compounds that can effectively control pests and diseases in agriculture, thereby contributing to increased crop yields and food security.
Used in Dye and Pigment Production:
Thiazol-4-amine is employed as a starting material in the synthesis of dyes and pigments for various applications, including textiles, plastics, and printing inks. Its ability to form stable and vibrant colorants makes it a valuable component in the colorants industry.
Used in Research and Development:
Thiazol-4-amine is also used in research and development settings for the exploration of new chemical reactions and the discovery of novel compounds with potential applications in various fields. Its versatility and reactivity make it a popular choice for chemists working on innovative projects.

InChI:InChI=1/C3H4N2S/c4-3-1-6-2-5-3/h1-2H,4H2

Upstream product

• 59134-92-8 4-trifluoroacetamidothiazole 

Downstream Products

• 71169-29-4 propynoic acid thiazol-4-ylamide 
• 25602-39-5 N-(thiazol-2-yl)formamide 
• 70346-31-5 N-thiazol-4-yl-diacetamide 
• 2719-23-5 2-acetamidothiazole 
• 71168-42-8 N-thiazol-2-yl-diacetamide 
• 71169-28-3 N-thiazol-4-yl-acrylamide 
• 2007-19-4 1-nitroso-2-naphthol-3,6-disulfonic acid 
• 1450920-26-9 4-(2-bromo-4-(trifluoromethyl)phenyl)-N-(thiazol-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1235395-41-1 4-(biphenyl-2-yloxy)-3-cyano-N-1,3-thiazol-4-ylbenzenesulfonamide 

Relevant articles and documents

Mechanism of azo coupling reactions. Part 34. Reactivity of five-membered ring heteroaromatic diazonium ions

The azo coupling reactions of six five-membered heteroaromatic diazonium ions with 2-naphthol-3,6-disulfonic acid are investigated kinetically at various pH values.The dependence of the measured rate constants on the acidity of the aqueous reaction system is evaluated.It can be shown that the 2-naphtholate-3,6-disulfonate trianion reacts 4E8 - 8E8 times faster than the 2-naphthol-3,6-disulfonate dianion.The rate constants of the six diazonium ions vary by more than four orders of magnitude.The logarithms of the rate constants of all comparable diazonium ions correlate linearly with 1H-nmr chemical shifts of the respective unsubstituted heteroaromatic parent compounds.An analogous correlation was found for azo couplings with substituted benzenediazonium ions.Diazotization of heteroaromatic amines does not go to completion, rather to an equilibrium.It is shown therefore that in acidic coupling systems the azo compound is only the kinetically controlled product.The thermodynamic products are 1-nitroso-2-naphthol-3,6-disulfonic acid and the heteroaromatic amine.

4-Aminothiazole

4-Aminothiazole is prepared in stable useful form by alkaline hydrolysis of 4-trifluoroacetamidothiazole. Also prepared are 4-sulfathiazole and 2-(4-thaizolyl)-indazole.