Catalytic N-Acylation of Cyclic Amines by Arylglyoxylic Acids via Radical-Radical Cross-Coupling
A methodical mechanistic investigation allowed for the catalytic N-acylation of secondary cyclic amine counterparts by arylglyoxylic acids through radical-radical coupling. The reaction proceeds via a twofold SET-promoted Cu(I)/Cu(II) catalytic cycle under mild conditions. An analogous reaction variant allows for the N-acylation in a one-pot fashion directly starting from a secondary cyclic amine even in the presence of a second amine or hydroxy group.
A METHOD FOR FLUORINATED RING-OPENING OF A SUBSTRATE
Disclosed herein, inter alia, are methods useful for making a fluoroalkyl amine and methods useful for making an α-oxygenated cyclic amine.
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Paragraph 0259; 0260; 0268
(2019/12/25)
Electrophilic C-H borylation and related reactions of B-H boron cations
Catalytic procedures are described for the amine-directed borylation of aliphatic and aromatic tertiary amine-boranes. Sequential double borylation is observed in cases where two or more C-H bonds are available that allow 5-center or 6-center intramolecular borylation. The HNTf2-catalyzed borylation of benzylamine-boranes provides a practical means for the synthesis of ortho-substituted arylboronic acid derivatives, suitable for Suzuki-Miyaura cross-coupling applications.
Prokofjevs, Aleksandrs,Jermaks, Janis,Borovika, Alina,Kampf, Jeff W.,Vedejs, Edwin
p. 6701 - 6711
(2014/01/06)
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