17735-98-7

Basic information

• Product Name: 13C,16C-DOCOSADIENOIC ACID
• Synonyms: 13C,16C-DOCOSADIENOIC ACID;DELTA 13 CIS 16 CIS DOCOSADIENOIC ACID;13-CIS,16-CIS-DOCOSADIENOIC ACID;C22:2;13Z,16Z-Docosadienoic Acid
• CAS NO: 17735-98-7
• Molecular Formula: C22H40O2
• Molecular Weight: 336.55
• Mol File: 17735-98-7.mol

Chemical Properties

• Boiling Point: 456.3±14.0 °C(Predicted)
• Appearance: /
• Density: 0.900±0.06 g/cm3(Predicted)
• Solubility: ≤10mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 13C,16C-DOCOSADIENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 13C,16C-DOCOSADIENOIC ACID(17735-98-7)
• EPA Substance Registry System: 13C,16C-DOCOSADIENOIC ACID(17735-98-7)

Safety Data

• Hazardous Substances Data: 17735-98-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
13C,16C-DOCOSADIENOIC ACID is used as a therapeutic agent for treating obesity and related metabolic disorders. As an agonist of FFAR4, it modulates glucose homeostasis and lipid metabolism, leading to improved insulin sensitivity and reduced inflammation.
Used in Nutritional Supplements:
13C,16C-DOCOSADIENOIC ACID is used as a dietary supplement to support healthy fatty acid intake and promote overall health. Its presence in various natural sources makes it a valuable addition to nutritional products for maintaining a balanced diet.
Used in Research Applications:
13C,16C-DOCOSADIENOIC ACID is used as a research tool for studying the role of FFAR4 in cellular processes and its potential as a target for drug development. It aids in understanding the mechanisms of ghrelin secretion and its implications in appetite regulation and energy balance.

references

[1]. x. lu, x. zhao, j. feng, et al. postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through gpr120 in isolated gastric ghrelin cells and mice. am. j. physiol. gastrointest. liver physiol. 303(3), g367-376 (2012). [2]. kimura i. omega-3 fatty acids and ffar4[j]. obesity and diabetes: energy regulation by free fatty acid receptors, 2016: 29.[3]. ma d w l, seo j, switzer k c, et al. n-3 pufa and membrane microdomains: a new frontier in bioactive lipid research[j]. the journal of nutritional biochemistry, 2004, 15(11): 700-706.

Upstream product

• 61012-47-3 methyl (13Z,16Z)-docosadienoate 

Downstream Products

• 1394295-82-9 ethyl (Z,Z)-13,16-docosadienoate 

Relevant articles and documents

Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists

The transient receptor potential vanilloid type-2 (TRPV2) protein is a nonselective Ca2+ permeable channel member of the TRPV subfamily, still considered an orphan TRP channel due to the scarcity of available selective and potent pharmacological tools and endogenous modulators. Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists. Both synthetic and endogenous antagonists exhibited differential inhibition against known TRPV2 agonists characterized by distinct kinetic profiles. These findings represent the first example of both synthetic and naturally occurring TRPV2 modulators with efficacy in the submicromolar/low-micromolar range, which will be useful for clarifying the physiopathological roles of this receptor, its regulation, and its targeting in pathological conditions.