Strecker reactions with hexacyanoferrates as non-toxic cyanide sources
The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.
Grundke, Caroline,Opatz, Till
supporting information
p. 2362 - 2366
(2019/05/17)
Redox-neutral α-cyanation of amines
α-Aminonitriles inaccessible by traditional Strecker chemistry are obtained in redox-neutral fashion by direct amine α-cyanation/N-alkylation or alternatively, α-aminonitrile isomerization. These unprecedented transformations are catalyzed by simple carboxylic acids.
Ma, Longle,Chen, Weijie,Seidel, Daniel
p. 15305 - 15308
(2012/10/29)
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