Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: Synthesis, crystallography, modeling, kinetic and cellular based studies
Botulinum neurotoxins (BoNTs) are the most lethal biotoxins known to mankind and are responsible for the neuroparalytic disease botulism. Current treatments for botulinum poisoning are all protein based and thus have a limited window of treatment opportun
?ilhár, Peter,Silvaggi, Nicholas R.,Pellett, Sabine,?apková, Kate?ina,Johnson, Eric A.,Allen, Karen N.,Janda, Kim D.
supporting information
p. 1344 - 1348
(2013/03/14)
FUNCTIONALIZATION OF CARBOXYLIC ACIDS OF THE ADAMANTANE AND BICYCLONONANE SERIES IN LIQUID BROMINE
Carboxylic acids of the adamantane and bicyclononane series react with nucleophilic reagents such as water or acetic acid in liquid bromine to give the corresponding hydroxy, acetoxy, and bromino derivatives.
Baklan, V. F.,Khil'chevskii, A. N.,Sologub, L. S.,Kukhar, V. P.
p. 1680 - 1683
(2007/10/02)
Synthese de quelques structures encombrees derivees de l'adamantane et de ses analogues par alkylation des ether d'enol trimethylsilyliques
Alkylation of trimethylsilyl enol ethers of 2,4-dimethyl-3-pentanone, cyclopentanone and cyclohexanone has been extended to alkylating agents with a cage structure (substituted or functionalized adamantyl, diamantyl, homoadamantyl and noradamantyl chlorides or bromides).This method affords some new cage structured aliphatic and alicyclic ketones.In some cases one observes a new TiCl4 promoted reaction where the bromine in the alkylating agent is replaced by chlorine.This work is a generalization of our previous extended studies on α-alkylation of ketones with tertiary alkylating agents.