177743-06-5 Usage
Uses
Used in Pharmaceutical Industry:
3-Chloro-2-ethoxypyridine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Chloro-2-ethoxypyridine serves as an essential intermediate for the production of pesticides and other agrochemicals. Its reactivity and functional groups enable the creation of compounds with effective pest control properties.
Used in Organic Synthesis:
3-Chloro-2-ethoxypyridine is utilized as a versatile building block in organic synthesis for the preparation of a wide range of organic compounds. Its chlorinated and ethoxy-substituted pyridine structure provides opportunities for further chemical modifications and the synthesis of novel molecules with diverse applications.
Safety Precautions:
Due to its toxic and corrosive nature, 3-Chloro-2-ethoxypyridine should be handled with appropriate protective equipment, such as gloves, goggles, and masks, to minimize exposure risks. It should be stored and used in a well-ventilated area to prevent the accumulation of harmful vapors.
Check Digit Verification of cas no
The CAS Registry Mumber 177743-06-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,7,4 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 177743-06:
(8*1)+(7*7)+(6*7)+(5*7)+(4*4)+(3*3)+(2*0)+(1*6)=165
165 % 10 = 5
So 177743-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8ClNO/c1-2-10-7-6(8)4-3-5-9-7/h3-5H,2H2,1H3
177743-06-5Relevant articles and documents
Rhodium-catalysed nucleophilic ring opening reaction of 1- and 3-ethoxy-5,8-epoxy-5,8-dihydroisoquinolines
Kelebekli, Latif
, p. 304 - 308 (2013)
2-Ethoxy-3- and 5-chloropyridines were obtained from 2,3- and 2,5-dichloropyridine. Reaction of 2,3- and 2,5-dichloropyridines with tBuLi in the presence of furan gave 1- and 3-ethoxy-5,8-epoxy-5,8-dihydroisoquinolines. The rhodium-catalysed ring-opening
Substituted 3,4-pyridynes: Clean cycloadditions
Connon, Stephen J.,Hegarty, Anthony F.
, p. 1245 - 1249 (2007/10/03)
The stabilisation of 3,4-pyridyne (1) by an alkoxy group adjacent to the ring nitrogen is reported. The regioselective lithiation of 2-ethoxy- (14), 2-methoxy- (18), 2-isopropoxy- (19) and 6-isopropoxy- (26) -3-chloropyridines with tertbutyllithium at low temperatures, followed by elimination of lithium chloride affords 2- and 6-alkoxy-3,4-pyridynes. These species are trapped m situ with furan in a Diels-Alder reaction to give 5-8 in 66-89% yield, and do not give products typical of polymerisation or nucleophilic addition to the 3,4-pyridyne intermediates. As a comparison treatment of 3-chloropyridine with furan and LDA gives only 19% of adduct (4). We also report the novel use of the isopropoxy (rather than methoxy) group in these systems, which can act as a heteroatomic electron donating group which inhibits a-lithiation by tert-butyllithium because of its increased steric bulk. The Royal Society of Chemistry 2000.
