Synthesis of substituted 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine as new scaffolds for potential bioactive compounds
The title compounds having different substituents on the heterocyclic framework were prepared by several methods from 2-acetamido-3-hydroxypyridine. The condensation of 2-protected-amino-3-hydroxypyridine with 2-chloroacrylonitrile or ethyl 2,3-dibromopro
The first enantioselective synthesis of 4-acetyl-3(R)- and 3(S)-(hydroxymethyl)-3,4-dihydro-2H-pyrido[3,2-b]oxazine
A novel short and enantioselective synthetic approach to pyridobenzoxazines is reported in which (R)- and (S)-3-(hydroxymethyl)-3,4- dihydro-2H-pyrido[3,2-b][1,4]oxazine were first synthesized from readily available chiral glycidyl derivatives.