177762-74-2

Basic information

• Product Name: 3-METHOXYBENZYLISOCYANIDE
• Synonyms: 3-METHOXYBENZYLISOCYANIDE
• CAS NO: 177762-74-2
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Mol File: 177762-74-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHOXYBENZYLISOCYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXYBENZYLISOCYANIDE(177762-74-2)
• EPA Substance Registry System: 3-METHOXYBENZYLISOCYANIDE(177762-74-2)

Safety Data

• Hazardous Substances Data: 177762-74-2(Hazardous Substances Data)

Usage

Physical State

Clear, colorless liquid

Odor

Strong odor

Use in Organic Synthesis

Reagent: Used as a reagent in organic chemical synthesis.
Applications: Particularly in the preparation of various pharmaceuticals and fine chemicals.

Versatile Building Block

Can undergo a variety of reactions:
Nucleophilic addition
Substitution
Allows for the creation of a wide range of different compounds.

Potential Uses

Pharmaceuticals: Used in pharmaceutical synthesis.
Fine Chemicals: Employed in the preparation of fine chemicals.
Novel Materials: Potential use in the development of novel materials.
Chemical Processes: Potential involvement in the development of new chemical processes.

Toxicity and Handling

Caution Required: Important to handle with caution.
Health Hazards: Due to its toxicity and potential health hazards, proper safety measures must be observed during handling and usage.

Upstream product

• 180208-01-9 N-(3-methoxybenzyl)formamide 
• 5071-96-5 3-METHOXYBENZYLAMINE 

Downstream Products

• 152575-90-1 2-<4-(3-methoxyphenyl)-5-oxazolyl>-4,5-diphenyloxazole 
• 100-47-0 benzonitrile 
• 152575-91-2 3-<5-(4,5-diphenyl-2-oxazolyl)-4-oxazolyl>phenol 
• 152575-92-3 methyl <3-<5-(4,5-diphenyl-2-oxazolyl)-4-oxazolyl>phenoxy>acetate 

Relevant articles and documents

Isocyanide 2.0

The isocyanide functionality due to its dichotomy between carbenoid and triple bond characters, with a nucleophilic and electrophilic terminal carbon, exhibits unusual reactivity in organic chemistry exemplified for example in the Ugi reaction. Unfortunately, the over proportional use of only a few isocyanides hampers novel discoveries about the fascinating reactivity of this functional group. The synthesis of a broad range of isocyanides with multiple functional groups is lengthy, inefficient, and exposes the chemist to hazardous fumes. Here we present an innovative isocyanide synthesis overcoming these problems by avoiding the aqueous workup which we exemplify by parallel synthesis from a 0.2 mmol scale performed in 96-well microtiter plates up to a 0.5 mol multigram scale. The advantages of our methodology include an increased synthesis speed, very mild conditions giving access to hitherto unknown or highly reactive classes of isocyanides, rapid access to large numbers of functionalized isocyanides, increased yields, high purity, proven scalability over 5 orders of magnitude, increased safety and less reaction waste resulting in a highly reduced environmental footprint. For example, the hitherto believed to be unstable 2-isocyanopyrimidine, 2-acylphenylisocyanides and even o-isocyanobenzaldehyde could be accessed on a preparative scale and their chemistry was explored. Our new isocyanide synthesis will enable easy access to uncharted isocyanide space and will result in many discoveries about the unusual reactivity of this functional group. This journal is

3-Phenyl-substituted imidazo[1,5-a]quinoxalin-4-ones and imidazo[1,5- a]quinoxaline ureas that have high affinity at the GABA(A)/benzodiazepine receptor complex

A series of imidazo[1,5-a]quinoxalin-4-ones and imidazo[1,5- a]quinoxaline ureas containing substituted phenyl groups at the 3-position was developed. Compounds within the imidazo-[1,5-a]quinoxaline urea series had high affinity for the GABA(A)/benzodiaze