- Design, synthesis, and antiproliferative evaluation of novel coumarin/2-cyanoacryloyl hybrids as apoptosis inducing agents by activation of caspase-dependent pathway
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A series of novel coumarin/2-cyanoacryloyl hybrids were prepared and evaluated for their in vitro anticancer activity. Among them, two analogs 5p and 5q showed promising antiproliferative activity against a panel of cancer cell lines, including A549, H157
- Zhang, Yu-Ying,Zhang, Qian-Qian,Song, Jia-Li,Zhang, Liang,Jiang, Cheng-Shi,Zhang, Hua
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Read Online
- Efficient Synthesis of Pyrido[3,2-c[coumarins via Silver Nitrate Catalyzed Cycloisomerization and Application to the First Synthesis of Polyneomarline C
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Herein, we report an efficient method for the synthesis of the pyrido[3,2-c[coumarin scaffold, one of the privileged heterocycle-fused coumarin scaffolds, via a AgNO 3-catalyzed cycloisomerization of 4-(propynylamino)coumarins obtained from div
- Han, Young Taek,Yoon, Jeong A
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- Synthesis and Antibacterial Activity Evaluation of Novel (E)-4-(4-((arylidene)amino)phenoxy)coumarin Derivatives
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A series of novel (E)-4-(4-((arylidene)amino)phenoxy)coumarin derivatives were synthesized from 4-hydroxycoumarin in three step reactions, and their antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas citri subsp. Citri (X
- Chen, Mei-Hang,Tang, Bang-Cheng,Zhang, Xun,Shu, Hua
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- Inverse design and synthesis of acac-coumarin anchors for robust TiO 2 sensitization
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An inverse design methodology suitable to assist the synthesis and optimization of molecular sensitizers for dye-sensitized solar cells is introduced. The method searches for molecular adsorbates with suitable photoabsorption properties through continuous
- Xiao, Dequan,Martini, Lauren A.,Snoeberger, Robert C.,Crabtree, Robert H.,Batista, Victor S.
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Read Online
- The legend of 4-aminocoumarin: Use of the Delepine reaction for synthesis of 4-iminocoumarin
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Use of the Delepine reaction for synthesis of 4-aminocoumarin from 4-chlorocoumarin was not successful. The product was 4-iminocoumarin instead of 4-aminocoumarin. The 4-iminocoumarin was characterized by elemental analysis and spectral studies (FT-IR, s
- Al-Amiery, Ahmed A.,Kadhum, Abdul Amir H.,Al-Majedy,Ibraheem, Hiba H.,Al-Temimi, Ali A.,Al-Bayati, Redah I.,Mohamad, Abu Bakar
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- Synthesis of novel coumarin substituted amide derivatives and their antibacterial activities
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A series of novel coumarin substituted amide derivatives were synthesized and evaluated for their antibacterial activities. Result indicated that compounds 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n, 3o and 3q exhibited excellent antibacterial activities against
- Chen, Mei-Hang,Lu, Dao-Wang,Zhang, Xun,Zhou, Zeng-Yan,Wang, Xiao-Bin,Shu, Hua
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Read Online
- Novel curcumin analogue hybrids: Synthesis and anticancer activity
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In this study, twenty curcumin analogue hybrids as potential anticancer agents through regulation protein of TrxR were designed and synthesized. Results of anticancer activity showed that 5,7-dimethoxy-3-(3-(2-((1E, 4E)-3-oxo-5-(pyridin-2-yl)penta-1,4-dien-1- yl)phenoxy)propoxy)-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one (compound 7d) could induce gastric cancer cells apoptosis by arresting cell cycle, break mitochondria function and inhibit TrxR activity. Meanwhile, western blot revealed that this compound could dramatically up expression of Bax/Bcl-2 ratio and high expression of TrxR oxidation. These results preliminarily show that the important role of ROS mediated activation of ASK1/MAPK signaling pathways by this title compound.
- Wang, Jie Quan,Wang, Xiaobin,Wang, Yang,Tang, Wen Jian,Shi, Jing Bo,Liu, Xin Hua
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Read Online
- Synthesis and biological evaluation of harmirins, novel harmine–coumarin hybrids as potential anticancer agents
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As cancer remains one of the major health burdens worldwide, novel agents, due to the development of resistance, are needed. In this work, we designed and synthesized harmirins, which are hybrid compounds comprising harmine and coumarin scaffolds, evaluat
- Beus, Maja,Kralj, Marijeta,Pavi?, Kristina,Poje, Goran,Raji?, Zrinka,Uzelac, Lidija
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- CHIRALITY SENSING WITH MOLECULAR CLICK CHEMISTRY PROBES
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The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and/or the concentration of the analyte in the sample, and/or the enantiomeric composition of the analyte in the sample is/are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite.
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Paragraph 0247
(2020/02/23)
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- A containing coumarin chalcone derivatives, preparation method and application thereof
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The invention discloses a containing coumarin chalcone derivatives, preparation method and application thereof, the general formula (I) are as follows: wherein: R is phenyl, substituted phenyl, aryl heterocyclic or substituted aryl heterocyclic radical, t
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Paragraph 0028; 0031
(2019/02/13)
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- Novel conjugates of podophyllotoxin and coumarin: Synthesis, cytotoxicities, cell cycle arrest, binding CT DNA and inhibition of Topo IIβ
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A series of conjugates of podophyllotoxin and coumarin were prepared using the click reaction, and their cytotoxicities against A549, HepG2, HeLa, and LoVo cells were evaluated. Among them, compound 14e exhibited the strongest cytotoxicities against these cancer cells with IC50 values of 4.9–17.5 μM. Furthermore, 14e disrupted microtubules and induced cell cycle arrest at G1 phase by regulating P21 and Cyclin D1 in LoVo cells. In addition, 14e bond CT DNA and selectively inhibited Topo IIβ over Topo IIα. Molecular docking model showed that 14e appeared to form stable hydrogen bonds with several DNA bases and residue Gln778. Taken together, these conjugates have the potential to be developed as anti-tumor drugs.
- Hao, Shu-Yi,Feng, Shi-Liang,Wang, Xing-Rong,Wang, Zhichao,Chen, Shi-Wu,Hui, Ling
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p. 2129 - 2135
(2019/07/05)
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- Design, synthesis and biological evaluation of novel coumarin-based hydroxamate derivatives as histone deacetylase (HDAC) inhibitors with antitumor activities
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A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC50 values, with the best compound (10e) being nearly 90 times more active than vorinostat (SAHA) against HDAC1. Compounds 10e and 11d also increased the levels of acetylated histone H3 and H4, which is consistent with their strong HDAC inhibition. In addition, 10e and 11d displayed a higher potency toward human A549 and Hela cancer cell lines compared with SAHA. Moreover, 10e and 11d significantly arrested A549 cells at the G2/M phase and enhanced apoptosis. Molecular docking studies revealed the possible mode of interaction of compounds 10e and 12a with HDAC1. Our findings suggest that these novel coumarin-based HDAC inhibitors provide a promising scaffold for the development of new potential cancer chemotherapies.
- Yang, Feifei,Zhao, Na,Song, Jiali,Zhu, Kongkai,Jiang, Cheng-shi,Shan, Peipei,Zhang, Hua
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- Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties
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A series of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties have been synthesized based on copper-catalyzed azide-alkyne cycloaddition (CuAAC). The anti-cancer activity of the new triazole nucleobase analogues was stud
- Zhao, Jian-Wei,Wu, Zeng-Hui,Guo, Jia-Wen,Huang, Ming-Jie,You, Ya-Zhen,Liu, Hong-Min,Huang, Li-Hua
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supporting information
(2019/08/12)
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- Benzothiazole-containing 1,4-pentadiene-3-one derivative as well as preparation method and application thereof
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The invention discloses a benzothiazole-containing 1,4-pentadienyl-3-one derivative, as well as a preparation method and application thereof. A general formula (I) is shown as the specification, wherein R is a phenyl group, a substituted phenyl or an aromatic heterocyclic group, the R-substituted phenyl group is one or more methyl or methoxy, trifluoromethyl, trifluoromethoxy, nitro, or one or more halogen atom-substituted phenyl group, and the R-substituted aromatic heterocyclic group is a thienyl group, a substituted naphthyl group or other heterocyclic groups. The benzothiazole-containing 1,4-pentadienyl-3-one derivative has relatively good resistance to tobacco mosaic virus, the reaction conditions are relatively mild, the post-treatment is simple, and the yield is relatively high.
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Paragraph 0028; 0031
(2019/01/23)
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- Cu (I) Catalyzed One Pot SN-Click Reactions of Halogenated Coumarins and 1-aza-coumarins
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A one pot three component, copper catalyzed azide-alkyne cycloaddition reaction has been employed for the synthesis of bis-coumarinyl triazoles (A–D) using 4-chloro, 4-bromomethyl, 3-bromoacetyl and 4-bromomethyl-1-aza-coumarins (I–IV), sodium azide, and coumarin propargyl ethers (V–IX) in moderate yields.
- Revankar, Hrishikesh M.,Kulkarni, Manohar V.
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p. 537 - 544
(2018/01/10)
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- Hydroxamic acids compound containing coumarin structure, application and preparation method of hydroxamic acids compound
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The invention provides hydroxamic acids HDACi which is novel in structure and contains a coumarin structure. The hydroxamic acids HDACi comprise pharmaceutically acceptable salts, metabolite, isomer,prodrug and the like. Meanwhile, the invention also discloses a preparation method of the compound. On the basis of a coumarin key structure module, a hydroxamic acid structural framework is introduced, a novel hydroxamic acids micromolecular organic compound which contains a coumarin structure is designed and synthesized, the compound has the advantages of coumarin and the advantages of hydroxamic acid, and the obtained compound which serves as a histone deacetylase inhibitor can be placed in drugs for preventing and treating cancers or inflammations; and the compound can further be used forinducing drugs for treating tumors after chemotherapy fails due to acquired drug resistance.
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- Coumarin derivative with alpha, beta-unsaturated ketone structure fragments as well as preparation method and purpose thereof
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The invention relates to the field of medicine and chemistry, in particular to a coumarin derivative with alpha, beta-unsaturated ketone structure fragments and antineoplastic activity. The structuregeneral formula of the coumarin derivative is shown in t
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Paragraph 0025-0027
(2018/11/04)
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- 1,4-disubstituted 1,2,3-triazole nucleoside analogues, and preparation method and application thereof
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The invention belongs to the technical field of pharmaceutical chemistry, and relates to 1,4-disubstituted 1,2,3-triazole nucleoside analogues: design, synthesis and anti-gastric cancer activity research. The purine nucleoside analogues have the following
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Paragraph 0074; 0076-0077
(2018/09/08)
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- 1,4-pentadiene-3-ketone derivative containing coumarin, and preparation method and application thereof
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The invention discloses a 1,4-pentadiene-3-ketone derivative containing coumarin. The 1,4-pentadiene-3-ketone derivative containing the coumarin is characterized in that a general formula is shown as follows: (shown in the description), wherein R1 is phenyl, substituted phenyl or substituted aromatic heterocyclic group; R2 is one or more of hydrogen atoms, methoxyl, nitryl, methyl, trifluoromethyl or halogen atoms contained on site 5, 6, 7 or 8 of the coumarin structure. The compound has excellent inhibition activity for stomach cancer SGC7901 cells and liver cancer hepG2 cells, has relatively high antitumor activity and can be used as a potential antitumor drug.
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Paragraph 0037-0038; 0042
(2017/08/30)
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- Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents
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A series of novel phosphoramidate derivatives of coumarin have been designed and synthesized as chitin synthase (CHS) inhibitors. All the synthesized compounds have been screened for their chitin synthase inhibition activity and antimicrobial activity in vitro. The bioactive assay manifested that most of the target compounds exhibited good efficacy against CHS and a variety of clinically important fungal pathogens. In particular, compound 7t with IC50 of 0.08 mM against CHS displayed stronger efficiency than the reference Polyoxin B with IC50 of 0.16 mM. In addition, the apparent Ki values of compound 7t was 0.096 mM while the Km of Chitin synthase prepared from Candida tropicalis was 3.86 mM for UDP-Nacetylglucosamine, and the result of the Ki showed that the compounds was a non-competitive inhibitor of the CHS. As far as the antifungal activity is concerned, compounds 7o, 7r and 7t were highly active against Aspergillus flavus with MIC values in the range of 1 μg/mL to 2 μg/Ml while the results of antibacterial screening showed that these compounds have negligible actions to the tested bacteria. These results indicated that the design of these compounds as antifungal agents was rational.
- Ji, Qinggang,Ge, Zhiqiang,Ge, Zhixing,Chen, Kaizhi,Wu, Hualong,Liu, Xiaofei,Huang, Yanrong,Yuan, Lvjiang,Yang, Xiaolan,Liao, Fei
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p. 166 - 176
(2015/12/04)
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- Synthesis, Cytotoxic Evaluation, and In Silico Studies of 4-Substituted Coumarins
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Two series of coumarins possessing the aniline- and heterocyclic ring at 4thposition have been synthesized and evaluated for their in vitro cytotoxic activity against MCF-7 cancer cell line in MTT assay. Structure activity relationship (SAR) studies reveal that the electron donor group at position-8 of coumarin played an important role in cytotoxic activity. Compound VIId showed the potent cytotoxic activity followed by compound Xa with IC50= 6.25 and 6.50 μM, respectively. A docking study has also been carried out for the most potent compound to get an insight into molecular interactions with p50 subunit of NF-κB protein.
- Kaur, Prabhjot,Gill, Rupinder Kaur,Singh, Gagandip,Bariwal, Jitender
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p. 1519 - 1527
(2016/09/23)
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- Pd-catalyzed chemo-selective mono-arylations and bis-arylations of functionalized 4-chlorocoumarins with triarylbismuths as threefold arylating reagents
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Cross-coupling reactions of differently substituted 4-chlorocoumarins were studied under palladium catalysis using triarylbismuths as threefold arylating reagents. The high reactivity of 4-chlorocoumarins was demonstrated delivering mono- and bis-arylation products in a chemo-selective manner. The reaction conditions employed are simple, robust and the threefold coupling reactivity of triarylbismuth reagents was witnessed with good to high yields in 2-4 h conditions. The utility of the methodology was explored in the synthesis of a few natural occurring neoflavones (3.27-3.30). In addition, the 4-arylcoumarin 3.1 product is a useful precursor for the preparation of (R)-tolterodine.
- Rao, Maddali L.N.,Kumar, Abhijeet
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p. 6995 - 7005
(2015/03/14)
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- Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents
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In this research, a series of 4-(1,2,3-triazol-1-yl)coumarin conjugates were synthesized and their anticancer activities were evaluated in vitro against three human cancer cell lines, including human breast carcinoma MCF-7 cell, colon carcinoma SW480 cell and lung carcinoma A549 cell. To increase the biological potency, structural optimization campaign was conducted focusing on the C-4 position of 1,2,3-triazole and the C-6, C-7 positions of coumarin. In addition, to further evaluate the role of 1,2,3-triazole and coumarin for antiproliferative activity, 9 compounds possessing 4-(piperazin-1-yl)coumarin framework and 3 derivatives baring quinoline core were also synthesized. By MTT assay in vitro, most of the compounds display attractive antitumor activities, especially 23. Further flow cytometry assays demonstrate that compound 23 exerts the antiproliferative role through arresting G2/M cell-cycle and inducing apoptosis.
- Zhang, Wenjuan,Li, Zhi,Zhou, Meng,Wu, Feng,Hou, Xueyan,Luo, Hao,Liu, Hao,Han, Xuan,Yan, Guoyi,Ding, Zhenyu,Li, Rui
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supporting information
p. 799 - 807
(2014/02/14)
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- Estimation of ground and excited state dipole moments of synthesized coumarin derivative [N-(2-oxo-2H-chromen-4-yl)imino]triphenyl-phosphorane
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Electronic absorption and fluorescence spectra of coumarin derivative [N-(2-oxo-2H-chromen-4-yl)imino] triphenyl phosphorane have been recorded at room temperature in wide range of solvents of different polarities. The absorption maximum remains almost un
- Joshi, Sunita,Kumari, Santosh,Bhattacharjee, Rituparna,Sakhuja, Rajeev,Pant, Debi D.
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p. 115 - 119
(2015/02/19)
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- In vitro antimicrobial and antimycobacterial activity of some chalcones and their derivatives
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In this study, novel series of chalcone derivatives, namely, 4-[4-(3-phenyl-acryloyl)-phenylamino]-chromen-2-one (5a-k) have been synthesized from the intermediate 4-(4-acetyl-phenylamino)-chromen-2-one (4). Cyclization reaction of chalcone (5a-k) with hydrazine hydrate, guanidine nitrate, and malononitrile gives the corresponding 4-[4-(1-acetyl-5-phenyl-4,5-dihydro-1H- pyrazol-3-yl)-phenylamino]-chromen-2-one (6a-k), 4-[4-(2-amino-6-phenyl- pyrimidin-4-yl)-phenylamino]-chromen-2-one (7a-k), and 2-amino-6-[4-(2-oxo-2H- chromen-4-ylamino)-phenyl]-4-phenyl-nicotinonitrile (8a-k) derivatives were synthesized. The newly synthesized compounds were evaluated for their antimycobacterial activity and antimicrobial activity against eight bacteria (S. aureus, B. cereus, E. coli, P. aeruginosa, K. pneumoniae, S. typhi, P. vulgaris, and S. flexneri) and four fungi (A. niger, C. albicans, A. fumigatus, and A. clavatus).
- Patel, Divyesh,Kumari, Premlata,Patel, Navin B.
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p. 726 - 744
(2013/04/24)
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- Synthesis of new substituted chromen[4,3-c]pyrazol-4-ones and their antioxidant activities
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A series of new coumarin derivatives 4 containing a 4-arylbut-3-en-2-one moiety were synthesized by condensation of 3-acetylcoumarin 1 with aryl aldehydes 2 in chloroform in the presence of piperidine. The interactions of 3-formyl-4-chlorocoumarin (3) with nitrogen-containg nucleophiles leading to the corresponding substituted chromen-[4,3- c]pyrazol-4-ones 5 are described. The structures of the obtained compounds were established on the basis of 1D NMR, 2D NMR and IR and further the compounds were evaluated for possible antioxidant activities. The coumarinic chalcone 4a has been found to be the most active (IC50 = 2.07 μM) in this study.
- Al-Ayed, Abdullah Sulaiman
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experimental part
p. 10292 - 10302
(2012/02/14)
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- A rapid access to new coumarinyl chalcone and substituted chromeno[4,3-c]pyrazol-4(1H)-ones and their antibacterial and DPPH radical scavenging activities
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A series of new coumarin derivatives 4 containing a chalcone moiety were synthesized by condensation of 3-acetyl-4-hydroxycoumarin 1 with aryl or heteroaryl aldehydes 2 in the presence of piperidine in chloroform. The interaction of 3-formyl-4-chloro-coumarin 3 with nitrogen compound nucleophiles are described and lead to the corresponding substituted chromen[4,3-c] pyrazol-4-ones 5. The structures of the obtained compounds were established on the basis of IR|1D|2D NMR, while crystal structure of 3-acetyl-4-hydroxy coumarin 1 was determined using X-ray diffraction and further were evaluated for possible antibacterial and antioxidant activities. The coumarinic chalcone 4d has been found to be the most active (IC50 = 2.07 μM) in this study.
- Hamdi, Naceur,Fischmeister, Cedric,Puerta, M. Carmen,Valerga, Pedro
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experimental part
p. 522 - 530
(2012/05/04)
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- Efficient one-pot synthesis of N-substituted 2-aminochromones, their benzo-fused derivatives, and diaminobenzodipyrandiones of two new structural classes
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N-Substituted 2-aminochromones and their benzo-fused derivatives were obtained in high yields by a new one-pot synthesis, starting from the appropriate acetamides, salicylic acid or its benzo-fused derivatives, and phosphoryl chloride. By the same reaction, from suitable dihydroxybenzenedicarboxylic acids, some compounds of two new structural classes, 2,7-diaminobenzo[1,2-b:4,5-b']dipyran-4,9-diones and 2,8-diamino-4H,6H-benzo[1,2-b:5,4-b']dipyran-4,6-diones, were synthesized. Georg Thieme Verlag Stuttgart.
- Roma, Giorgio,Piras, Daniela,Di Braccio, Mario,Grossi, Giancarlo
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experimental part
p. 849 - 857
(2010/10/02)
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- A facile transformation of 2-aminochromone to 4-chlorocoumarin and its reaction with ethylenediamine
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2-Aminochromones 1a-c and 8a-c are converted into 4-chlorocoumarins 2a-c and 9a-c. On treatment with ethylenediamine, 2a-c produce 2,3,4,5-tetrahydro-7- (2′-hydroxyphenyl)-1,4-diazepin-5-one 3a,b and 4-(2-aminoethyl) aminocoumarin 4b,c in ethanol; while i
- Ghosh, Tarun,Sur, Kumar Ranabir,Bandyopadhyay, Chandrakanta
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p. 651 - 654
(2007/10/03)
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- Symmetrical bisquinolones via metal-catalyzed cross-coupling and homocoupling reactions
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Functionalized 4,4′-bisquinolones can be efficiently synthesized by microwave-assisted palladium(0)-catalyzed one-pot borylation/Suzuki cross-coupling reactions or via nickel(0)-mediated homocouplings of 4-chloroquinolin-2(1H)-one precursors. Both methods are also applicable to other types of symmetrical biaryls.
- Hashim, Jamshed,Glasnov, Toma N.,Kremsner, Jennifer M.,Kappe, C. Oliver
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p. 1707 - 1710
(2007/10/03)
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- Studies of bioactive heterocycles: Amino Claisen rearrangement of 4-N-(4-aryloxybut-2-ynyl),N-methylaminocoumarins
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Thermalamino-Claisen rearrangement of 4-N-(aryloxybut-2-ynyl),N-methyl-aminocoumarins (8a-e) in refluxing o-dichlorobenzene gave 4-aryloxymethylene-1-methyl-1,2,3-trihydropyrido[3,2-c][1]benzopyran-5-ones (9a-e) in 56-72% isolated yields. Substrates (8a-f) were prepared from 4-chlorocoumarin (6a,b) and N-(4-ary-loxybutynyl),N-methylamine (7a-f) in 68-77% yields.
- Majumdar,Bhattacharyya
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p. 4231 - 4233
(2007/10/03)
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- Nucleophilic Vinylic Substitution of Halocoumarins and Halo-1,4-naphthoquinones with morpholine
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Reactions of morpholine with 4-halocoumarins 1, 3-halocoumarins 3, and 2-halo-1,4-naphthoquinones 8 yield two different products, one where halogen is replaced by a nucleophile at the same carbon and the other where the nucleophile is attached to the vici
- Oh, Changsok,Yi, Inwoo,Park, Kyong Pae
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p. 841 - 844
(2007/10/02)
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- Heterocyclic -Condensed Coumarins from 4-Azido-3-coumarincarbaldehydes
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4-Azido-3-coumarincarbaldehydes 2a-d are useful starting materials for syntheses of a variety of 3,4-disubstituted coumarins as well as heterocyclic -fused coumarins, e. g. isoxazoles, pyrazoles and 1,5-diazepines, under mild conditions.In these reacti
- Steinfuehrer, Thorsten,Hantschmann, Achim,Pietsch, Michael,Weissenfels, Manfred
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- Methods for the Synthesis of 4-Azido-2(1H)-quinolones
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4-Hydroxy-2-quinolones 1 are generally found to be converted to the 4-azidocompounds 3 via the 4-chloroquinolones 2, the 4-tosyloxyquinolones 6, or the 4-aminoquinolones 4, respectively.Choice of the reaction conditions and yields depend on the substituen
- Stadlbauer, Wolfgang
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p. 1305 - 1324
(2007/10/02)
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