- Synthesis and inotropic activity of 1-(O-aminoalkyloximes) of perhydroindene derivatives as simplified digitalis-like compounds acting on the Na+,K+-ATpase
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A series of 5-substituted (3aS,7aR)-7a-methylperhydroinden-3a-o1 derivatives bearing a 1(S)-(ω-aminoalkoxy)iminoalkyl or -alkenyl substituent was synthesized, starting from the Hajos-Parrish ketol 47, as simplified analogues of very potent 17β-aminoalkylo
- Cerri,Almirante,Barassi,Benicchio,De Munari,Marazzi,Molinari,Serra,Melloni
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p. 189 - 207
(2007/10/03)
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- 1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same
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1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): STR1 where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and A is (CH=CH)m (CH2)n OR, (CH=CH)m (CH2)n NR1 R2, (CH=CH)m (CH2)p B, OH, O(CH2)q OR, O(CH2)q NR1 R2 or O(CH2)r B; q is an integer from 2 to 5; r is an integer from 1 to 2; or the symbol - - - - represents a double bond, A is oxygen, CH(CH=CH)s (CH2)n OR, CH(CH=CH)s (CH2)n NR1 R2 or CH(CH=CH)s (CH2)p B; and L is ?CH=C(R3)!s CH=NR4 or ?CH=C(R3)!s CH2 NHR4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.
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