178671-88-0

Basic information

• Product Name: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-(9CI)
• Synonyms: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-(9CI);1,5,8,8a-tetrahydro-3(2H)-Indolizinone
• CAS NO: 178671-88-0
• Molecular Formula: C8H11NO
• Molecular Weight: 137.17904
• Product Categories: AMINETERTIARY
• Mol File: 178671-88-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-(9CI)(178671-88-0)
• EPA Substance Registry System: 3(2H)-Indolizinone,1,5,8,8a-tetrahydro-(9CI)(178671-88-0)

Safety Data

• Hazardous Substances Data: 178671-88-0(Hazardous Substances Data)

Upstream product

• 1378306-68-3 (S)-methyl 4-((S)-1,1-dimethylethylsulfinamido)hept-6-enoate 
• 287974-07-6 (S)-5-Allyl-1-((S)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-one 
• 287974-10-1 (S)-1,5-diallylpyrrolidin-2-one 
• 2555-14-8 N-allylsuccinimide 
• 82259-09-4 (racemic)-5-(2'-propenyl)-2-pyrrolidinone 
• 87449-77-2 5-ethoxy-1-(2'-propen-1'-yl)-2-pyrrolidinone 
• 178671-87-9 1,5-diallyl-pyrrolidin-2-one 
• 82259-09-4 (5S)-(+)-5-(1-Prop-2-enyl)-2-pyrrolidinone 

Downstream Products

• 142796-65-4 (8aR)-perhydro-3-indolizidinone 

Relevant articles and documents

Synthesis of 5-Substituted 2-Pyrrolidinones by Coupling of Organozinc Reagents with Cyclic N-Acyliminium Ions

A coupling reaction between cyclic N-acyliminium ions with organozinc reagents is described. The cyclic N-acyliminium ions, generated in situ from N-substituted-5-hydroxy-2-pyrrolidinones by treatment with boron trifluoride-diethyl ether complex or titani

A versatile enantioselective synthesis of azabicyclic ring systems: A concise total synthesis of (+)-grandisine D and unnatural analogues

Closing in on azacines: We have developed a new six step approach for the rapid and enantioselective synthesis of indolizidine, pyrrolo[1,2-a]azepine, and pyrrolo[1,2-a]azocine azabicyclic systems and their respective lactam congeners, which are found in a host of natural products as well as pharmaceutical preparations. This protocol enables a concise enantioselective total synthesis of (+)-grandisine D in 16.4 % overall yield from commercial materials (see scheme). Copyright

Concise synthesis of indolizidines: Total synthesis of (-)-coniceine

The Ti-mediated allylsilane addition to bicyclic lactams occurs with high stereoselectivity and combined with a ring closure metathesis provides the title compounds in high ee.

β-, γ- and δ-Lactams as conformational constraints in ring-closing metathesis

The azabicycloalkenones 5, 6 and 7 were formed in excellent yields via ring-closing metathesis of the bis-alkenyl precursors 1, 2 and 3.