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CAS

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179033-51-3

TiMcodar, also known as tariquidar, is a third-generation P-glycoprotein inhibitor with high potency in combating drug resistance in cancer cells. It functions by inhibiting the P-glycoprotein, a protein that actively expels anticancer drugs from cancer cells, thereby enhancing the effectiveness of chemotherapy. TiMcodar has demonstrated promising results in preclinical and clinical trials, showing potential as a valuable tool in the battle against multidrug-resistant cancers. Its good safety profile and tolerability when combined with other chemotherapy medications further underscore its potential in cancer treatment.

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  • 179033-51-3 Structure

  • Basic information

    1. Product Name: TiMcodar
    2. Synonyms: TiMcodar;VX 853;VX-853;Timcodar ,VX-853;(2S)-N-benzyl-3-(4-chlorophenyl)-N-(1,5-dipyridin-4-ylpentan-3-yl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]amino]propanamide
    3. CAS NO:179033-51-3
    4. Molecular Formula: C43H45ClN4O6
    5. Molecular Weight: 749.2936
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 179033-51-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: TiMcodar(CAS DataBase Reference)
    10. NIST Chemistry Reference: TiMcodar(179033-51-3)
    11. EPA Substance Registry System: TiMcodar(179033-51-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 179033-51-3(Hazardous Substances Data)

179033-51-3 Usage

Uses

Used in Oncology:
TiMcodar is used as a P-glycoprotein inhibitor for enhancing the effectiveness of chemotherapy drugs in treating multidrug-resistant cancers. By preventing the removal of anticancer drugs from cancer cells, TiMcodar helps overcome drug resistance and improve therapeutic outcomes.
Used in Drug Resistance Management:
TiMcodar is used as a therapeutic agent for managing drug resistance in cancer treatment. Its ability to inhibit P-glycoprotein makes it a promising candidate for improving the efficacy of chemotherapy in resistant cases, thereby increasing the chances of successful cancer treatment.
Used in Combination Therapy:
TiMcodar is used as an adjunct to other chemotherapy medications for combination therapy in cancer treatment. Its good safety profile and tolerability when used in combination with other drugs make it a valuable component in multidrug treatment regimens, potentially leading to better patient outcomes and improved cancer management.

Check Digit Verification of cas no

The CAS Registry Mumber 179033-51-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,0,3 and 3 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 179033-51:
(8*1)+(7*7)+(6*9)+(5*0)+(4*3)+(3*3)+(2*5)+(1*1)=143
143 % 10 = 3
So 179033-51-3 is a valid CAS Registry Number.

179033-51-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-N-benzyl-3-(4-chlorophenyl)-N-(1,5-dipyridin-4-ylpentan-3-yl)-2-[methyl-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]amino]propanamide

1.2 Other means of identification

Product number -
Other names VX 853

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:179033-51-3 SDS

179033-51-3Upstream product

179033-51-3Downstream Products

179033-51-3Relevant articles and documents

Amino acid derivatives with improved multi-drug resistance activity

-

, (2008/06/13)

The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmac

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