179056-82-7

Basic information

• Product Name: 4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE
• Synonyms: 4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)BENZALDEHYDE;2-(4-Formylphenyl)-5-methyl-1,3,4-oxadiazole;Benzaldehyde,4-(2H-1,2,3-triazol-2-yl)-;4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzaldehyde 97%;4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzaldehyde97%
• CAS NO: 179056-82-7
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18
• Mol File: 179056-82-7.mol

Chemical Properties

• Boiling Point: 354.3°Cat760mmHg
• Flash Point: 168.1°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE(179056-82-7)
• EPA Substance Registry System: 4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE(179056-82-7)

Safety Data

• Hazardous Substances Data: 179056-82-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE is used as a building block in organic synthesis for the creation of various organic molecules. Its unique structure allows it to be a valuable component in the formation of complex organic compounds, contributing to the advancement of chemical research and the development of new materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE is used as a building block for the development of new drugs. Its potential biological activities and pharmacological properties make it a promising candidate for the creation of innovative therapeutic agents, potentially leading to breakthroughs in medicine.
Used in Research and Development:
4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE is utilized in research and development across various industries. Its specific applications may vary depending on the needs and objectives of the research, but its potential for contributing to scientific advancements is evident. 4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BENZALDEHYDE's role in the discovery and development of new technologies and products is significant, as it can be adapted to meet the demands of different fields.

InChI:InChI=1/C10H8N2O2/c1-7-11-12-10(14-7)9-4-2-8(6-13)3-5-9/h2-6H,1H3

Upstream product

• 179055-96-0 4-(((tert-butyldimethylsilyl)oxy)methyl)benzohydrazide 
• 25877-46-7 4-(5-methyl-1,3,4-oxadiazol-2-yl)phenol 
• 15226-74-1 dicobalt octacarbonyl 
• 41421-03-8 5-(4-bromophenyl)-2-methyl-1,3,4-oxadiazole 
• 1571-08-0 methyl 4-formylbenzoate 
• 139706-48-2 4-(tert-butyldimethylsilyloxymethyl)benzoic acid methyl ester 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 179055-97-1 2-[4-(tert-Butyl-dimethyl-silanyloxymethyl)-phenyl]-5-methyl-[1,3,4]oxadiazole 

Downstream Products

• 1383719-88-7 C₂₆H₃₀N₄O₄ 
• 1394898-84-0 C₂₂H₃₀N₄O₃ 
• 1333471-70-7 2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)-1-(5-(3,4,5-trimethoxyphenyl)furan-2-yl)ethanone 
• 1333472-40-4 N,2-dimethoxy-N-methyl-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1333472-39-1 2-methoxy-2-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl)acetic acid 
• 179056-43-0 Cycloheptyl-[4-(5-methyl-[1,3,4]oxadiazol-2-yl)-benzyl]-amine 

Relevant articles and documents

Palladium-Catalyzed Reductive Carbonylation of (Hetero) Aryl Halides and Triflates Using Cobalt Carbonyl as CO Source

An efficient protocol for the reductive carbonylation of (hetero) aryl halides and triflates under CO gas-free conditions using Pd/Co2(CO)8 and triethylsilane has been developed. The mild reaction conditions, enhanced chemoselectivity and, easy access to heterocyclic and vinyl carboxaldehydes highlights its importance in organic synthesis.

Inhibitors of acyl-coA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N- (heteroaryl-substituted benzyl)-N'-arylureas

A series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylurea and related derivatives represented by 2 and 3 have been prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyltransferase in vitro and to lower plasma cholesterol levels in cholesterol-fed rats in vivo. Among these novel compounds, the type 3 series was superior. A pyrazol-3-yl group on the N-benzyl group of this trisubstituted urea (i.e. 3, Ar1 = pyrazol-3- yl) was identified as a heteroaromatic ring providing a good profile of biological activity. As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (At3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0.44 mg/kg administered by gavage in PEG400 vehicle). Moreover, a toxicological study revealed compound 3aq to be nontoxic to the adrenal glands of dogs when tested at a single dose of 10 mg/kg po.