179057-29-5 Usage
Uses
Used in Pharmaceutical Industry:
4-(1H-PYRAZOL-3-YL)BENZALDEHYDE is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into a wide range of drug molecules, contributing to the development of new therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 4-(1H-PYRAZOL-3-YL)BENZALDEHYDE is used as a building block for the preparation of agrochemical compounds. Its ability to form stable complexes with other molecules makes it a valuable component in the development of effective pesticides and other agricultural chemicals.
Used in Organic Synthesis:
4-(1H-PYRAZOL-3-YL)BENZALDEHYDE is used as a reagent in organic synthesis. Its reactive aldehyde group allows it to participate in various chemical reactions, making it a useful tool for the synthesis of complex organic molecules.
Used in Heterocyclic Compound Preparation:
As a building block, 4-(1H-PYRAZOL-3-YL)BENZALDEHYDE is used for the preparation of heterocyclic compounds. Its pyrazole ring provides a stable and versatile platform for the construction of diverse heterocyclic structures with potential applications in various fields.
Used in Chemical Intermediate Synthesis:
4-(1H-PYRAZOL-3-YL)BENZALDEHYDE serves as a precursor for the synthesis of other important chemical intermediates. Its presence in the molecular structure of these intermediates can significantly influence their properties and potential uses in various industries.
Due to its diverse applications and the potential for further development in medicinal and material chemistry, 4-(1H-PYRAZOL-3-YL)BENZALDEHYDE has garnered significant interest from the scientific and industrial communities.
Check Digit Verification of cas no
The CAS Registry Mumber 179057-29-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,0,5 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 179057-29:
(8*1)+(7*7)+(6*9)+(5*0)+(4*5)+(3*7)+(2*2)+(1*9)=165
165 % 10 = 5
So 179057-29-5 is a valid CAS Registry Number.
179057-29-5Relevant articles and documents
Inhibitors of acyl-coA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N- (heteroaryl-substituted benzyl)-N'-arylureas
Tanaka, Akira,Terasawa, Takeshi,Hagihara, Hiroyuki,Sakuma, Yuri,Ishibe, Noriko,Sawada, Masae,Takasugi, Hisashi,Tanaka, Hirokazu
, p. 2390 - 2410 (2007/10/03)
A series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylurea and related derivatives represented by 2 and 3 have been prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyltransferase in vitro and to lower plasma cholesterol levels in cholesterol-fed rats in vivo. Among these novel compounds, the type 3 series was superior. A pyrazol-3-yl group on the N-benzyl group of this trisubstituted urea (i.e. 3, Ar1 = pyrazol-3- yl) was identified as a heteroaromatic ring providing a good profile of biological activity. As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (At3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0.44 mg/kg administered by gavage in PEG400 vehicle). Moreover, a toxicological study revealed compound 3aq to be nontoxic to the adrenal glands of dogs when tested at a single dose of 10 mg/kg po.
