179106-93-5

Basic information

• Product Name: Tert-Butyl 2-Bromo-2-(Diethoxyphosphoryl)Acetate
• Synonyms: Tert-Butyl 2-Bromo-2-(Diethoxyphosphoryl)Acetate
• CAS NO: 179106-93-5
• Molecular Formula: C₁₀H₂₀BrO₅P
• Molecular Weight: 363.139361
• Mol File: 179106-93-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Tert-Butyl 2-Bromo-2-(Diethoxyphosphoryl)Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-Butyl 2-Bromo-2-(Diethoxyphosphoryl)Acetate(179106-93-5)
• EPA Substance Registry System: Tert-Butyl 2-Bromo-2-(Diethoxyphosphoryl)Acetate(179106-93-5)

Safety Data

• Hazardous Substances Data: 179106-93-5(Hazardous Substances Data)

Upstream product

• 179106-94-6 dibromo(diethoxyphosphoryl)acetic acid tert-butyl ester 
• 7772-99-8 stannous chloride 
• 27784-76-5 tert-butyl diethylphosphonoacetate 

Downstream Products

• 848758-62-3 3-(2-tert-butoxycarbonyl-2-naphthalen-1-yl-vinyl)-4,6-dichloro-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 179106-77-5 (Z)-2-(2,4-dichlorophenyl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid, t-butyl ester 
• 179106-71-9 (Z)-2-(4-Methoxyphenyl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)propenoic acid, t-butyl ester 
• 179107-00-7 (Z)-2-(4-Chlorophenyl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)-propenoic acid, t-butyl ester 
• 179105-88-5 (E)-3-(2-(tert-butoxycarbonyl)-2-phenylvinyl)-4,6-dichloro-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 179328-04-2 3-(2-tert-butoxycarbonyl-2-thiophen-3-yl-vinyl)-4,6-dichloro-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 179328-06-4 3-(2-tert-butoxycarbonyl-2-thiophen-2-yl-vinyl)-4,6-dichloro-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 179328-08-6 (E)-2-(fur-2-yl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)propenoic acid, t-butyl ester 
• 179328-10-0 (E)-2-(fur-3-yl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)propenoic acid, t-butyl ester 
• 179106-70-8 (Z)-3-(2-bromo-2-(tert-butoxycarbonyl)vinyl)-4,6-dichloro-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

AROMATIC HETEROCYCLIC SUBSTITUTED OLEFIN COMPOUND, PREPARATION METHOD FOR SAME, PHARMACEUTICAL COMPOSITION OF SAME, AND APPLICATIONS THEREOF

Provided in the present application are an aromatic heterocyclic substituted olefin compound, a preparation method for same, a pharmaceutical composition of same, and applications thereof. The aromatic heterocyclic substituted olefin compound of the present invention is a novel ALK5 inhibitor and is for use in treating and/or preventing various ALK5-mediated diseases.

Multisubstituted Cyclohexene Construction through Telescoped Radical-Addition Induced Remote Functional Group Migration and Horner–Wadsworth–Emmons (HWE) Olefination

An efficient telescoped method for the rapid assembly of multisubstituted cyclohexenes is presented herein. The whole process nicely merges photoredox-promoted alkene difunctionalization via remote functional group migration with concomitant intramolecular Horner–Wadsworth–Emmons (HWE) olefination. The characteristic feature of this protocol resides in the fact that the follow-up requiring ketone functionality for ring-closing olefination is in situ unveiled from the otherwise inert tertiary alcohol by the preceding alkene difunctionalization.

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2- arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-Aminophenyl)-2- carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist

(E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and selective antagonist of the glycine site of the N-methyl-D-aspartate (NMDA) receptor. Using 3D comparative molecular field analysis (CoMFA) to guide the synthetic effort, a series of aryl diacid analogues of 1 were synthesized to optimize in vivo potency, duration of action, and binding activity. It was found that the incorporation of a substituted aromatic with an electron withdrawing group or a heterocyclic group at the 2-position of the 3-propenyl moiety of 1 gave compounds with better affinity and potency in the murine stroke model. Ultimately this led to the discovery of 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, 19, as a new potent selective glycine-site NMDA receptor antagonist.

3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof

The present invention is new 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof. These new 3-indolyl-3-yl-prpopenoic acid derivatives are useful as NMDA antagonist.