- Thienodipyridine derivatives, production and use thereof
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A compound of the formula (I): wherein R is hydrogen or C2-6alkanoyl; X is halogen; and ring A is benzene ring which is optionally substituted by 1 to 4 substituents selected from {circle around (1)} halogen, {circle around (2)} hydroxy, {circl
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- Thienopyridine derivatives and their use
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PCT No. PCT/JP97/01413 Sec. 371 Date Jun. 26, 1997 Sec. 102(e) Date Jun. 26, 1997 PCT Filed Apr. 23, 1997 PCT Pub. No. WO97/40050 PCT Pub. Date Oct. 30, 1997There is disclosed a compound of the formula (A): wherein W is C-G or C-G' (G is optionally esterified carboxyl; and G' is halogen); X is oxygen, optionally oxidized sulfur or -(CH2)q- (q is 0 to 5); R is optionally substituted amino or heterocyclic group; the ring B is optionally substituted nitrogen-containing 5- to 7-membered ring; L is hydrogen, optionally substituted hydrocarbon residue, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted thiocarbamoyl or optionally substituted sulfonyl provided that, when W is C-G, L is hydrogen, optionally substituted acyl, optionally substituted carbamoyl, optionally substituted alkoxycarbonyl, optionally substituted thiocarbamoyl or optionally substituted sulfonyl; n is 0 or 1; the ring A may have a substituent. A process for producing the compound (A) and a pharmaceutical composition containing the compound (A) are also disclosed. The pharmaceutical composition is useful for an anti-inflammatory drug, particularly, a drug for preventing or treating arthritis, a drug for inhibiting bone resorption, immunosuppressant or the like.
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- Studies on disease-modifying antirheumatic drugs. IV. Synthesis of novel thieno[2,3-b : 5,4-c']dipyridine derivatives and their anti-inflammatory effect
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The syntheses and anti-inflammatory activities of novel thieno[2,3- b]pyridine and thieno[2,3-b:5,4-c']-dipyridine derivatives are described. These compounds were designed by modification of the quinoline template of a new type of disease-modifying antirh
- Baba, Atsuo,Mori, Akira,Yasuma, Tsuneo,Unno, Satoko,Makino, Haruhiko,Sohda, Takashi
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p. 993 - 999
(2007/10/03)
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