- Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-l,2,5-thiadiazol-3-yl)-l,2,5,6-tetrahydro-l-methylpyridine. Synthesis, receptor affinity, and antinociceptive activity
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Conformationally constrained analogues of the potent muscarinic agonist 3-(4-(methylthio)l,2,5-thiadiazol-3-yl)-l,2,5,6-tetrahydro-l-methylpyridine (methylthio-TZTP, 17) were designed and synthesized with the aim of (a) improving the antinociceptive selec
- Sauerberg, Per,Olesen, Preben H.,Sheardown, Malcolm J.,Rimvall, Karin,Th?gersen, A Henning,Shannon, Harlan E.,Sawyer, Barry D.,Ward, John S.,Bymaster, Frank P.,Delapp, Neil,Calligaro, David O.,Swedberg, Michael D. B.
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p. 109 - 116
(2007/10/03)
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- Heterocyclic compounds and their preparation and use
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The present invention relates to therapeutically active azacyclic or azabicyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nerv
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