- HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS
-
The present invention generally relates to compounds that inhibit haematopoietic-prostaglandin D2 synthase (H-PGDS), to compositions containing them and to their use in treating or preventing conditions and diseases associated with H-PGDS, such
- -
-
-
- INDANE DERIVATES AS MUSCARINIC RECEPTOR AGONISTS
-
The present invention relates to compounds of Formula I: I which are agonists of the M-1 muscarinic receptor.
- -
-
-
- PIPERIDINES USEFUL FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
-
The invention relates to compounds which are substituted chiral or achiral derivatives of 3- or 4- aminopiperidine of the general formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula I and especially their use as inhibitors of β-secretases.
- -
-
-
- MUSCARINIC AGONISTS
-
The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.
- -
-
-
- MUSCARINIC AGONISTS
-
The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.
- -
-
-
- Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework
-
The use of a catalyst system based on Pd2dba3· CHCl3 and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha- adamantane allows for Suzuki coupling aryl halides with an array of boronic acids on a solid-phase platform. The reactions can be carried out at room temperature with low palladium loadings in high yields.
- Ohnmacht, Stephan A.,Brenstrum, Tim,Bleicher, Konrad H.,McNulty, James,Capretta, Alfredo
-
p. 5661 - 5663
(2007/10/03)
-
- Inhibitors of farnesyl-protein transferase
-
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent
- -
-
-