179545-77-8

Basic information

• Product Name: Tanomastat
• Synonyms: TANOMASTAT;BAY12-9566,(S)-4Chloro-g-oxo-a-[(phenylthio)methyl][1,1biphenyl]-4-butanoicAcid;(S)-4'-Chloro-g-oxo-a-[(phenylthio)methyl][1,1'-biphenyl]-4-butanoic acid;(S)-4-[4-(4-Chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid;D03802;Tanomastat (usan/inn);(S)-4-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic acid
• CAS NO: 179545-77-8
• Molecular Formula: C23H19ClO3S
• Molecular Weight: 410.91
• Product Categories: Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 179545-77-8.mol

Chemical Properties

• Melting Point: 110-110.5°C
• Boiling Point: 620.1°C at 760mmHg
• Flash Point: 328.8°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 3.07E-16mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: -20°C Freezer
• Solubility: Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (S
• PKA: 4.01±0.23(Predicted)
• CAS DataBase Reference: Tanomastat(CAS DataBase Reference)
• NIST Chemistry Reference: Tanomastat(179545-77-8)
• EPA Substance Registry System: Tanomastat(179545-77-8)

Safety Data

• Hazardous Substances Data: 179545-77-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tanomastat is used as a Matrix Metalloproteinase inhibitor for its ability to inhibit the activity of MMP-2, MMP-3, and MMP-9, which are enzymes involved in the breakdown of extracellular matrix proteins. This inhibition can help prevent tumor metastasis and angiogenesis, making it a potential therapeutic agent for various types of cancer.
Used in Oncology:
Tanomastat is used as an angiogenesis inhibitor for its ability to prevent the formation of new blood vessels that supply nutrients to tumors, thereby limiting their growth and spread. This application makes it a valuable tool in the fight against cancer, particularly in the treatment of pancreatic, SCLC, NSCLC, and ovarian cancer.
Used in Drug Development:
Tanomastat is used as a research compound for the development of new drugs targeting MMPs and angiogenesis. Its potent inhibitory activity and demonstrated efficacy in animal models make it a promising candidate for further investigation and potential clinical use.
Chemical Properties:
Tanomastat is a white solid with an optical rotation of +82° (C 1.5 acetone), indicating its chiral nature and potential for further chemical modification and optimization.

InChI:InChI=1/C23H19ClO3S/c24-20-12-10-17(11-13-20)16-6-8-18(9-7-16)22(25)14-19(23(26)27)15-28-21-4-2-1-3-5-21/h1-13,19H,14-15H2,(H,26,27)/t19-/m1/s1

Relevant articles and documents

Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)xA—B—D—E—G wherein A is an aryl or heteroaryl rings; B is an aryl or heteroaryl ring or a bond; each T is a substituent group; x is 0, 1, or 2; the group D represents the group E represents a two or three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents and with the proviso that when G is each of the substituents on E is an independent substituent; and include pharmaceutically acceptable salts thereof.