- Interaction of polycationic Ni(II)-salophen complexes with G-quadruplex DNA
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A series of nine Ni(II) salophen complexes involving one, two, or three alkyl-imidazolium side-chains was prepared. The lengths of the side-chains were varied from one to three carbons. The crystal structure of one complex revealed a square planar geometr
- Lecarme, Laureline,Prado, Enora,De Rache, Aurore,Nicolau-Travers, Marie-Laure,Bonnet, Romaric,Heyden, Angeline Van Der,Philouze, Christian,Gomez, Dennis,Mergny, Jean-Louis,Jamet, Hlne,Defrancq, Eric,Jarjayes, Olivier,Thomas, Fabrice
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- NiH-Catalyzed Reductive Relay Hydroalkylation: A Strategy for the Remote C(sp3)?H Alkylation of Alkenes
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The terminal-selective, remote C(sp3)?H alkylation of alkenes was achieved by a relay process combining NiH-catalyzed hydrometalation, chain walking, and alkylation. This method enables the construction of unfunctionalized C(sp3)?C(sp3) bonds under mild conditions from two simple feedstock chemicals, namely olefins and alkyl halides. The practical value of this transformation is further demonstrated by the large-scale and regioconvergent alkylation of isomeric mixtures of olefins at low catalyst loadings.
- Zhou, Fang,Zhu, Jin,Zhang, Yao,Zhu, Shaolin
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supporting information
p. 4058 - 4062
(2018/03/21)
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- Interaction of functionally-substituted 4-alkyl-2,6-di-tert-butylphenols with hydrohalic acids
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Reactions of 4-alkyl-2,6-di-tert-butylphenols containing OH, SH, COOH, and COOMe groups in their para substituents with hydrogen chloride and hydrohalic acids were studied. One-step transformations of 2,6-di-tert-butyl-4-(ω- hydroxyalkyl)phenols to the corresponding 4-(ω-halogenoalkyl)phenols, as well as of 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid and its esters to phloretic acid were proposed. 4-(3-Mercaptopropyl)phenol upon heating with conc. HBr undergoes condensation to 3-(4-hydroxyphenyl)propyl 4-(3-mercaptopropyl)phenyl sulfide as the main product.
- Prosenko,Skorobogatov,Dyubchenko,Pinko,Kandalintseva,Shakirov,Pokrovsky
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p. 1119 - 1124
(2008/09/18)
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- Radical-mediated carboxylation of alkyl iodides with [11C]carbon monoxide in solvent mixtures
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(Chemical Equation Presented) [carboxyl-11C]Carboxylic acids were prepared from alkyl iodides via photoinitiated radical reactions using 10-8 mol of [11C]carbon monoxide in binary and ternary homogeneous solvent mixtures. Short-(isobutyric), medium-, and long-chain saturated fatty acids (heptadecanoic) were labeled with isolated decay-corrected radiochemical yields ranging from 55% to 70% in 5-7-min reactions. The conversion of [11C]carbon monoxide to products reached 80-90%. To obtain good yields in the reactions performed in water-acetonitrile and water-THF mixtures, the addition of tetrabutylammonium hydroxide or potassium hydroxide was essential. The carboxylation was efficient for primary and secondary alkyl iodides. The carboxylation of tertiary iodides was feasible for 1-iodoadamantane but not for tert-butyl iodide. The dependence of the radiochemical yields on reaction time, photoirradiation conditions, and organic and inorganic additives was studied. The method provides a one-step route to [carboxyl-11C]carboxylic acids; traditional methods, in contrast, would require several steps. For example, using the devised reaction conditions, 3.19 GBq of purified [1-11C]1,10-decanedicarboxylic acid (specific radioactivity 188 GBq/μmol) was obtained within 35 min of the end of 10 μAh bombardment. (1-13C)4-Phenylbutyric acid was synthesized using (13C)-carbon monoxide for identifying the labeling position with 1H and 13C NMR.
- Itsenko, Oleksiy,Langstroem, Bengt
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p. 2244 - 2249
(2007/10/03)
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