- Dichloromeldrum's acid (DiCMA): A practical and green amine dichloroacetylation reagent
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Dichloromeldrum's acid is introduced as a bench-stable, nonvolatile reagent for the dichloroacetylation of anilines and alkyl amines to produce α,α-dichloroacetamides, which are important motifs for medicinal chemistry. Products are formed in good to excellent yields with reagent grade solvents, and, as the only byproducts are acetone and CO2, no column chromatography is required. Thus, this reagent is practical, efficient, and green for the dichloroacetylation of primary amines.
- Heard, David M.,Lennox, Alastair J.J.
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supporting information
p. 3368 - 3372
(2021/05/06)
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- Design, Synthesis, Molecular Docking and Biological Activity of New Piperidine and Piperazine Derivatives of Dichloroacetate as Potential Anticancer Agents
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Dichloroacetate (DCA) is a small anticancer agent acting through inhibition of pyruvate dehydrogenase kinases (PDKs) and preventing proliferation of tumor growth. In this study, a series of new piperidine and piperazine derivatives of DCA were designed an
- Fereidoonnezhad, Masood,Manouchehrizadeh, Elham,Mostoufi, Azar,Tahanpesar, Elham
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