The first total synthesis of (+)-conagenin, a novel immunomodulator produced by Streptomyces roseosporus, has been achieved in highly stereo- and enantioselective manner. The carboxylic acid moiety was synthesized starting with asymmetric aldor reaction of propiophenone with acetaldehyde followed by in situ syn-selective NaBH4 reduction. The amin acid moiety was synthesized based upon Et2AlCl catalyzed cyclization of the epoxy trichloroacetimidate prepared from (S)-methylglycidol. Condensation of both moieties and alkaline hydrolysis led to (+)-conagenin.
Spiro piperidines and homologs promote release of growth hormone
There are disclosed certain novel compounds identified as spiro piperidines and homologs which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such spiro compounds as the active ingredient thereof are also disclosed.
-
(2008/06/13)
More Articles about upstream products of 179862-73-8