179930-11-1

Basic information

• Product Name: (R,E)-2-(benzo[d][1,3]dioxol-5-ylMethyleneaMino)-2-phenylethanol
• Synonyms: (R,E)-2-(benzo[d][1,3]dioxol-5-ylMethyleneaMino)-2-phenylethanol
• CAS NO: 179930-11-1
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.2952
• Mol File: 179930-11-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R,E)-2-(benzo[d][1,3]dioxol-5-ylMethyleneaMino)-2-phenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R,E)-2-(benzo[d][1,3]dioxol-5-ylMethyleneaMino)-2-phenylethanol(179930-11-1)
• EPA Substance Registry System: (R,E)-2-(benzo[d][1,3]dioxol-5-ylMethyleneaMino)-2-phenylethanol(179930-11-1)

Safety Data

• Hazardous Substances Data: 179930-11-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R,E)-2-(benzo[d][1,3]dioxol-5-ylmethyleneamino)-2-phenylethanol is used as a pharmaceutical intermediate for the development of new drugs due to its unique structure and functional groups that can be further modified or used in the synthesis of bioactive molecules.
Used in Organic Synthesis:
In the field of organic synthesis, (R,E)-2-(benzo[d][1,3]dioxol-5-ylmethyleneamino)-2-phenylethanol serves as a key building block for the creation of more complex organic molecules, potentially leading to the discovery of novel compounds with specific applications.
Used in Materials Science:
(R,E)-2-(benzo[d][1,3]dioxol-5-ylmethyleneamino)-2-phenylethanol may be utilized in materials science for the development of new materials with unique properties, such as improved stability, reactivity, or selectivity in various chemical processes.

Upstream product

• 120-57-0 piperonal 
• 122-98-5 2-Anilinoethanol 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 

Downstream Products

• 157341-41-8 L-694,458 

Relevant articles and documents

An efficient large-scale process for the human leukocyte elastase inhibitor, DMP 777

This report describes a new convergent, selective, and economical synthesis of DMP 777, ending with the coupling of the chiral β-lactam half of the molecule (1) to the chiral amine as the isocyanate (2). Other steps involve the coupling of the β-lactam 3 to the phenolic moiety under phase-transfer conditions, followed by resolution of the resulting piperazine derivative using a chiral acid, and recycling of the undesired enantiomer also under phase-transfer conditions. The chiral amine 4 was produced efficiently starting from (R)-α-methylbenzylamine and the corresponding butyrophenone.