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2,2,2-Trifluoro-1-(4-methoxy-phenyl)-ethylamine is a chemical compound characterized by the molecular formula C10H12F3NO. It features a fluorinated amine structure with a trifluoromethyl group and a 4-methoxy-phenyl group attached to the nitrogen atom. 2,2,2-TRIFLUORO-1-(4-METHOXY-PHENYL)-ETHYLAMINE is known for its unique chemical properties and is of interest to researchers in various scientific fields.

179996-42-0

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179996-42-0 Usage

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1-(4-methoxy-phenyl)-ethylamine is utilized as a building block in the synthesis of biologically active molecules, particularly those targeting psychiatric and neurological disorders. Its unique structure allows for the development of potential therapeutic agents that can address these conditions more effectively.
Used in Materials Science:
In the field of materials science, 2,2,2-Trifluoro-1-(4-methoxy-phenyl)-ethylamine may have potential applications in the development of new functionalized polymers and supramolecular materials. Its distinct chemical properties make it a promising candidate for creating innovative materials with specific functionalities and improved performance characteristics.

Check Digit Verification of cas no

The CAS Registry Mumber 179996-42-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,9,9 and 6 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 179996-42:
(8*1)+(7*7)+(6*9)+(5*9)+(4*9)+(3*6)+(2*4)+(1*2)=220
220 % 10 = 0
So 179996-42-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H10F3NO/c1-14-7-4-2-6(3-5-7)8(13)9(10,11)12/h2-5,8H,13H2,1H3

179996-42-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2,2-trifluoro-1-(4-methoxyphenyl)ethanamine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:179996-42-0 SDS

179996-42-0Downstream Products

179996-42-0Relevant articles and documents

Silver-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides: a facile stereoselective synthesis of CF3-substituted heterocycles

Zhang, Xue,Wang, Xin,Gao, Yuelei,Xu, Xianxiu

supporting information, p. 2427 - 2430 (2017/03/01)

An Ag-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides with polar double bonds has been developed for the facile access to trifluoromethylated oxazolines, imidazolines and pyrrolines under mild conditions. The practicality of this chemistry is demonstrated by the gram-scale synthesis of oxazolines with excellent yields and facile transformations of the formed oxazolines to trifluoromethylated β-amino alcohols in quantitative yields.

BF3-promoted aromatic substitution of N-alkyl α-trifluoromethylated imine: Facile synthesis of 1-aryl-2,2,2-trifluoroethylamines

Gong, Yuefa,Kato, Katsuya,Kimoto, Hiroshi

, p. 2637 - 2645 (2007/10/03)

The aromatic substitution of three representative N-alkyl trifluoromethyl imines 1a-c (R: a, benzyl; b, benzhydryl; c, methyl), obtained from primary alkyl amines and trifluoroacetaldehyde ethyl hemiacetal, was used to investigate the preparation of 1-aryl-2,2,2-trifluoroethylamines. In the presence of BF3·OEt2, the reaction of imine 1 with various aromatic compounds proceeded smoothly at room temperature, giving N-alkyl-1-aryl-2,2,2-trifluoroethylamines in moderate-to-high yields. Moreover, successful regioselective removal of N-benzyl and N-benzhydryl groups was achieved by hydrolysis in hydrochloric acid or by palladium-catalyzed hydrogenolysis.

Mechanisms of decomposition of (Z)-2,2,2-trifluoro-1-arylethanediazoates in aqueous media

Finneman, Jari I.,Fishbein, James C.

, p. 7134 - 7138 (2007/10/03)

A study of the kinetics of decay of three (Z)-2,2,2-trifluoro-1-arylethanediazoates at 25°C in aqueous media, 4% 2-propanol by volume, ionic strength 1 M (NaClO4) in the pH range 4-13, as well as the results of experiments to detect deuterium incorporation into products from solvent is reported. It is concluded in the case of the unsubstituted compound that the buffer-independent reaction involves rate-limiting heterolytic bond fission of the diazoic acid to yield a diazonium ion intermediate, and a similar mechanism is indicated for the other two compounds. General acid catalysis of the decay of the diazoic acids at pH 7 is observed, and it is concluded that the reaction involves rate-limiting N-O bond cleavage of the diazoic acid that is concerted with protonation of the leaving hydroxide ion by the catalyst.

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