cas 180083-23-2, 1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE | Articles data ｜lookchem

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180083-23-2

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Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists
Novel piperidine derivatives of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use as medicaments for the treatment of CNS disorders are disclosed.
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(2008/06/13)

The selective 5-HT(1B) receptor inverse agonist 1-methyl-5-[[2'-methyl- 4'(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7- tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function bo
5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT(1B) and 5-HT(1D) receptors (previously known as 5-HT(1Dβ) and 5- HT(1Dα), respectively), although e
Gaster, Laramie M.,Blaney, Frank E.,Davies, Susannah,Duckworth, D. Malcolm,Ham, Peter,Jenkins, Sarah,Jennings, Andrew J.,Joiner, Graham F.,King, Frank D.,Mulholland, Keith R.,Wyman, Paul A.,Hagan, Jim J.,Hatcher, Jon,Jones, Brian J.,Middlemiss, Derek N.,Price, Gary W.,Riley, Graham,Roberts, Claire,Routledge, Carol,Selkirk, Julie,Slade, Paula D.
p. 1218 - 1235
(2007/10/03)

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Chemical Properties

Melting Point: >280℃
Boiling Point: 724.8±70.0 °C(Predicted)
Density: 1.34
Solubility:DMSO: 4.5 mg/mL
Storage Temp.:Store at RT
PKA: 9.85±0.20(Predicted)
PSA: 71.70000
LogP: 6.38400

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