1,3-Dipolar cycloaddition route to nitrogen heterocyclic triones
1,3-Dipolar cycloaddition of nitrile oxides, formed in situ by dehydration of primary nitro compounds, with pyrrolidine enamines of protected γ- or δ-amino-β-keto esters affords isoxazole-4-carboxylates; these undergo lactam formation and N-O bond cleavage to afford 3-acyltetramic acids and 3-acyl-4-hydroxypyridin-2-ones.
Jones, Raymond C. F.,Bhalay, Gurdip,Carter, Paul A.,Duller, Kathryn A. M.,Dunn, Stephen H.
p. 765 - 776
(2007/10/03)
More Articles about upstream products of 180295-80-1