Iridium-Catalyzed C4-Alkylation of 2,6-Di-tert-butylphenol by Using Hydrogen-Borrowing Catalysis
An iridium-catalyzed hydrogen-borrowing process has been developed whereby 2,6-di-tert-butylphenol can be alkylated at the C4-position by using a range of primary alcohols (11 examples, 40-93% yield). Following this, a selection of the products obtained underwent retro-Friedel-Crafts reactions to provide para-substituted phenols, which could potentially undergo further synthetic manipulations.
Frost, James R.,Cheong, Choon Boon,Donohoe, Timothy J.
p. 910 - 916
(2017/02/15)
THERMODYNAMIC PRINCIPLES OF TRANSALKYLATION OF STERICALLY HINDERED PHENOLS
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Nesterova, T. N.,Verevkin, S. P.,Rempel', R. D.,Merdzhanov, V. R.,Roshchupkina, I. Yu.
p. 1635 - 1638
(2007/10/02)
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