- Stereochemistry of the Palladium-catalyzed Hydrogenation of 3-Oxo-4-ene Steroids. V. A Kinetic Study in Basic and Acidic Media
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Effects of the β-methyl group at C-10 and some oxygen functions (=O, OH, OAc) at C-11, C-17, and C-20 on the rates of hydrogenation of 3-oxo-4-ene steroids have been studied with palladium catalyst in pyridine or THF/HBr as solvent.In contrast to the hydrogenation in pyridine, the rate in THF/HBr was greatly depressed by the presence of 10β-methyl group.The reactivity of the steroids was enhanced by the oxygen functions, in particular, by 11, 17-dioxo group.The effects of the substituents are discussed from a mechanistic consideration based on the obtained results.
- Nishimura, Shigeo,Momma, Yasuhiro,Kawamura, Hideo,Shiota, Michio
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p. 780 - 783
(2007/10/02)
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- Oxidation process
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A novel liquid phase oxidation process using silver silicate as the oxidizing agent which is particularly adapted for oxidation of a hydroxy attached to a carbon atom to a carbonyl group.
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