- New series of green cyclic ammonium-based room temperature ionic liquids with alkylphosphite-containing anion: Synthesis and physicochemical characterization.
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A new series of 12 cyclic ammonium-based room temperature ionic liquids (RTILs) containing an alkylphosphite anion have been synthesized by an alkylation reaction between cyclic tertiary amines and dialkylphosphite. This method constitutes an eco-friendly
- Zarrougui, Ramzi,Raouafi, Noureddine,Lemordant, Daniel
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- Synthesis and extraction behavior of alkyl and cyclic aminophosphonates towards actinides
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Alkyl and cyclic substituted aminophosphonates (AmPs) were synthesized and characterized with various spectroscopic techniques. The molecular structures of diphenyl phenyl aminophosphonate (DPhPhAmP) and diphenyl cyclohexyl aminophosphonate (DPhCyAmP) wer
- Das, Dhrubajyoti,Brahmmananda Rao,Sivaraman,Sivaramakrishna, Akella,Vijayakrishna, Kari
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- Lipid-mimicking phosphorus-based glycosidase inactivators as pharmacological chaperones for the treatment of Gaucher's disease
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Gaucher's disease, the most prevalent lysosomal storage disorder, is caused by missense mutation of the GBA gene, ultimately resulting in deficient GCase activity, hence the excessive build-up of cellular glucosylceramide. Among different therapeutic strategies, pharmacological chaperoning of mutant GCase represents an attractive approach that relies on small organic molecules acting as protein stabilizers. Herein, we expand upon a new class of transient GCase inactivators based on a reactive 2-deoxy-2-fluoro-β-d-glucoside tethered to an array of lipid-mimicking phosphorus-based aglycones, which not only improve the selectivity and inactivation efficiency, but also the stability of these compounds in aqueous media. This hypothesis was further validated with kinetic and cellular studies confirming restoration of catalytic activity in Gaucher cells after treatment with these pharmacological chaperones.
- Clarke, Lorne,Overkleeft, Hermen S.,Robinson, Kyle,Santana, Andrés G.,Scherer, Manuel,Withers, Stephen G.,Zhou, Steven
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p. 13909 - 13913
(2021/11/04)
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- Synthesis of Branched Biolubricant Base Oil from Oleic Acid
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The mature manufacturing of synthetic lubricants (poly-α-olefins, PAO) proceeds through oligomerization, polymerization, and hydrogenation reactions of petrochemical ethylene. In this work, we utilize the inexpensive bio-derived oleic acid as raw material to synthesize a crotch-type C45 biolubricant base oil via a full-carbon chain synthesis without carbon loss. It contains several cascade chemical processes: oxidation of oleic acid to azelaic acid (further esterification to dimethyl azelate) and nonanoic acid (both C9 chains). The latter is then selectively hydrogenated to nonanol and brominated to the bromo-Grignard reagent. In a next step, a C45 biolubricant base oil is formed by nucleophilic addition (NPA) of excessive C9 bromo-Grignard reagent with dimethyl azelate, followed by subsequent hydrodeoxygenation. The specific properties of the prepared biolubricant base oil are almost equivalent to those of the commercial lubricant PAO6 (ExxonMobil). This process provides a new promising route for the production of value-added biolubricant base oils.
- Chen, Shuang,Wu, Tingting,Zhao, Chen
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p. 5516 - 5522
(2020/09/07)
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- Method for preparing phosphorus-based extreme pressure anti-wear agent capable of avoiding corrosion or rust formation on metal surface
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The present invention relates to a method for preparing a phosphorus-based extreme pressure anti-wear agent, comprising: mixing phosphorus trichloride and benzene in a reaction bottle with nitrogen gas circulating in the bottle to obtain a reaction mixtur
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Paragraph 0019-0029
(2019/08/26)
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- A convenient two-step synthesis of dialkylphosphate ionic liquids
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Dialkylphosphate ionic liquids are useful solvents for cellulose dissolution and catalytic reactions. In this paper, a new methodology for the synthesis of hydrophobic phosphate-based ionic liquids is described. This method involves the oxidation reaction of an easily prepared H-phosphonate precursor by using the environmentally friendly and inexpensive oxidizing agent hydrogen peroxide.
- Kotlarska, Justyna,Binnemans, Koen,Dehaen, Wim
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p. 9947 - 9950
(2013/11/06)
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- Convenient preparation of long-chain dialkyl phosphates: Synthesis of dialkyl phosphates
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Reaction of phosphorus oxychloride with a primary alcohol (1.8 equiv) and triethylamine (1.8 equiv) in toluene, followed by filtration and treatment with steam, gives dialkyl phosphates in good yield and essentially free from trialkyl phosphate contamination. Georg Thieme Verlag Stuttgart · New York.
- Aitken, R. Alan,Collett, Chris J.,Mesher, Shaun T. E.
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scheme or table
p. 2515 - 2518
(2012/09/05)
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- GELLED HYDROCARBONS FOR OILFIELD PROCESSES, PHOSPHATE ESTER COMPOUNDS USEFUL IN GELLATION OF HYDROCARBONS AND METHODS FOR PRODUCTION AND USE THEREOF
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Phosphate esters useful for gelling hydrocarbons in combination with a metal source are disclosed along with methods of preparation of the phosphate esters. Fouling in oil refinery towers has been attributed due to distillation of impurities present in phosphate esters used to gel hydrocarbons for oil well fracturing. The improved method of preparation of the phosphate ester results in a product that substantially reduces or eliminates volatile phosphorus, which is phosphorus impurities that distill up to 250° C., and increases the high temperature viscosity of the hydrocarbon gels formed using the phosphate esters.
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Page/Page column 7
(2011/04/14)
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- Synthesis of N-phosphoamino Acids With Long Dialkoxyl Chains
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In this paper, a series of N-phosphoamino acids with long dialkoxyl chains were synthesized with phosphites and amino acid esters. The data of these compounds were given.
- Deng, Chang-Hui,Li, Yan-Mei,Xu, Ning,Zhao, Yu-Fen
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p. 2552 - 2560
(2007/10/03)
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- Syntheses und NMR-Spektren phosphororganischer Antioxidantien und verwandter Verbindungen
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The syntheses of various aliphatic, aromatic, sterically hindered, and cyclic organophosphorus compounds (phosphorous acid esters, esters chlorides and ester amides, hydrogen phosphites, phosphinates and phosphates) are reported, and general procedures for preparation are given.The compounds synthesized were investigated by means of 31P-, 1H- and 13C-n.m.r. spectroscopy, and the chemical shifts measured are listed.
- Koenig, T.,Habicher, W.D.,Haehner, U.,Pionteck, J.,Rueger, C.,Schwetlick, K.
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p. 333 - 349
(2007/10/02)
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- A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES
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The Michaelis-Becker-Nylen reaction is well suited for the synthesis of 2-phosphonomethyl pyridines.We have improved this four steps method in a one pot reaction using commercial reagents.By this general procedure we have prepared seven new 2-phosphonomethyl pyridines (Ia-g) under mild conditions with higher yields.Key words: 2-phosphono pyridines; 2-phosphonomethyl pyridines; Michaelis-Becker-Nylen reaction; new phosphonates; potential ligands.
- Page, Patrick,Mazieres, Marie-Rose,Bellan, Jacques,Sanchez, Michel
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p. 205 - 210
(2007/10/02)
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