cas 180916-16-9, Lasofoxifene | Articles data

Articles about 180916-16-9Total 7 be found

Article title
Article abstract
Author
Journal number and time
Download

LASOFOXIFENE MODULATION OF MEMBRANE-INITIATED ESTROGEN SIGNALS AND METHODS FOR TUMOR TREATMENT
The present invention found that lasofoxifene is an antagonist of ER-α36. It not only inhibits the growth of ER-α36 positive lung, colon and gastric cancers, and also it can inhibit the growth of acquired or de novo tamoxifen-resistant MCF-7 cells. Our finding also provides methods and compositions for treating cancer comprising lasofoxifene alone or in combination with at least one other agent selected from the group consisting of gefitinib and/or trastuzumab or functional equivalent thereof, and an inhibitor in hormonal or epidermal growth factor signal transduction pathways.
-
(2018/08/03)

Total synthesis of lasofoxifene and nafoxidine
An intramolecular reductive coupling process of diketone with low-valent titanium species to form a dihydronapthalene skeleton was an important step in the synthesis of nafoxidine (1) and lasofoxifene (2). Diketone 6 was prepared in a convenient, three-st
Umareddy, Pailla,Arava, Veera Reddy
supporting information
p. 309 - 313
(2016/04/05)

PROCESS FOR PRODUCTION OF LASOFOXIFENE OR ANALOGUE THEREOF
Disclosed is a novel process for production of lasofoxifene, nafoxidine or an analogue thereof, which comprises reduced number of reaction steps, has a high efficiency, and is practically advantageous. For the production of lasofoxifene or an analogue the
-
Page/Page column 21-22; 30

(2008/12/04)

Pharmaceutical composition having uniform drug distribution and potency
Pharmaceutical compositions having uniform drug distribution and potency utilizing laxofoxifene as an active ingredient and containing a silicon dioxide to reduce loss of the active ingredient during the manufacturing process and methods for manufacturing such compositions are disclosed.
-
(2008/06/13)

Method for manufacturing a low dose pharmaceutical composition having uniform drug distribution and potency
A method for manufacturing a pharmaceutical composition having uniform drug distribution and potency is described which utilizes silicon dioxide to reduce the loss of active ingredient during the manufacturing process. The method is particularly useful for the manufacture of low dosage tablet compositions.
-
(2008/06/13)

Enzyme-catalyzed asymmetric deacylation for the preparation of Lasofoxifene (CP-336156), a selective estrogen receptor modulator
(Matrix presented) A potent and selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from
Yang, Xiaojing,Reinhold, Anthony R.,Rosati, Robert L.,Liu, Kevin K.-C
p. 4025 - 4027
(2007/10/03)

Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene [1]
-
Rosati,Jardine,Cameron,Thompson,Hua Zhu Ke,Toler,Brown,Pan,Ebbinghaus,Reinhold,Elliott,Newhouse,Tjoa,Sweetnam,Cole,Arriola,Gauthier,Crawford,Nickerson,Pirie,Qi,Simmons,Tkalcevic
p. 2928 - 2931
(2007/10/03)

Chemical Properties

Melting Point: 110-113°C
Boiling Point: 572.4 °C at 760 mmHg
Flash Point:300 °C
Density: 1.15 g/cm³
Solubility:Chloroform (Slightly), Methanol (Slightly)
Storage Temp.:Refrigerator
Vapor Pressure: 1.05E-13mmHg at 25°C
Refractive Index: 1.613
PKA: 10.31±0.60(Predicted)
PSA: 32.70000
LogP: 5.66660

Global suppliers and manufacturers of 180916-16-9total 38 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Shanghai Upbio Tech Co.,Ltd
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:30
Country:

Qingdao Beluga Import and Export Co., LTD
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:117
Country:

Shandong Hanjiang Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:No Data
Main Products:78
Country:

Henan Wentao Chemical Product Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:44
Country:

Hebei Nengqian Chemical Import and Export Co., LTD
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 1.0-10.0 / Kilogram
Main Products:165
Country:

Zibo Hangyu Biotechnology Development Co., Ltd
Business Type:Lab/Research institutions
Min Order:10 Gram
FOB Price:USD $ 100.0-100.0 / Gram
Main Products:313
Country:

Xiamen Jenny Chemical Technology Co., Ltd.
Business Type:Trading Company
Min Order:1 Milligram
FOB Price:No Data
Main Products:33
Country:

Hangzhou Dingyan Chem Co., Ltd
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:95
Country:

Hubei Taiho Chemical Co.,LTD
Business Type:Manufacturers
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Xi`an Eastling Biotech Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:21
Country:

Henan Tianfu Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:67
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Guangdong Juda Chemical Industrial Co.,Limited
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:30
Country:

Hangzhou Fandachem Co.,Ltd
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:52
Country:

Henan Kanbei Chemical Co.,LTD
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:61
Country:

Hangzhou ZeErRui Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:89
Country:

SAGECHEM LIMITED
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:33
Country:

BOC Sciences
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:41
Country:

Chemlyte Solutions
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:198
Country:

Shanghai Chinqesen Biotechnology Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:79
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 180916-16-9

Article Database

180916-16-9

Articles about 180916-16-9Total 7 be found

More Articles about upstream products of 180916-16-9

More Articles about downstream products of 180916-16-9

Chemical Properties

Melting Point: 110-113°C

Boiling Point: 572.4 °C at 760 mmHg

Flash Point:300 °C

Density: 1.15 g/cm³

Solubility:Chloroform (Slightly), Methanol (Slightly)

Storage Temp.:Refrigerator

Vapor Pressure: 1.05E-13mmHg at 25°C

Refractive Index: 1.613

PKA: 10.31±0.60(Predicted)

PSA: 32.70000

LogP: 5.66660

Global suppliers and manufacturers of 180916-16-9total 38 suppliers on LookChem

Article Database

180916-16-9

Articles about 180916-16-9Total 7 be found

More Articles about upstream products of 180916-16-9

More Articles about downstream products of 180916-16-9

Chemical Properties

Melting Point: 110-113°C

Boiling Point: 572.4 °C at 760 mmHg

Flash Point:300 °C

Density: 1.15 g/cm3

Solubility:Chloroform (Slightly), Methanol (Slightly)

Storage Temp.:Refrigerator

Vapor Pressure: 1.05E-13mmHg at 25°C

Refractive Index: 1.613

PKA: 10.31±0.60(Predicted)

PSA: 32.70000

LogP: 5.66660

Global suppliers and manufacturers of 180916-16-9total 38 suppliers on LookChem

Density: 1.15 g/cm³