- Synthese de 2,3,4,4a,9,9a-Hexahydro-11-indenopyrazines, Analogues Rigides de 3-Methyl-2-phenylpiperazines et Antidepresseurs Potentiels
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The synthesis of various diastereoisomeric (+/-) trans-(VIII) and cis-2,3,4,4a,9,9a-hexahydro-1H-indenopyrazines (IX) is described, using as key step for piperazine ring formation an alkoxyphosphonium salt.Compound VIIIa was prepared as a potential serotonin reuptake inhibitor.
- Chahboun, S.,Gelbcke, M.,Vliedt, G. Van De,Smith, D. F.
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p. 287 - 296
(2007/10/03)
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- Stereoselective Construction of Vicinal Diamines. Part 2. Synthesis of Indenopyrazines
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The trans-adduct 8 derived from indene and N,N-dichlorourethane serves as a precursor for the cis-1,2-diaminoindane 6 and the trans-diamines 7 and 14.Conversion of 6 and 14 into the triazabenzocycloheptafluorenes 1 and 2, respectively, via the indenopyrazines 4 and 5 is described.
- Orlek, Barry S.,Lightowler, Diane
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p. 1307 - 1312
(2007/10/02)
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