- MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS
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Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of
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Paragraph 0266; 0269-0270
(2014/09/29)
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- Process for brominating ergot alkaloids
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The present invention provides an improved process for the production of a compound of formula I STR1 wherein R1 is carboxyl, alkoxy(C1-5)carbonyl, amido, alkyl(C1-5)amido, di(alkyl(C1-5)amido or an amido radical of formula II STR2 wherein Ra is alkyl(C1-4), Rb is alkyl(C1-4) or benzyl, and R2 is hydrogen or alkyl(C1-4), and either R3 is hydrogen and R4 is hydrogen or alkoxy(C1-4) or R3 and R4 together are a single bond, characterized in that a compound of formula III STR3 wherein R1 to R4 are as defined above, is brominated with a bromine complex of 3-bromo-6-chloro-2-methyl-imidazo[1,2-b]pyridazine.
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