181289-10-1Relevant articles and documents
Enzymatic preparation of homochiral 2-isobutyl succinic acid derivatives
Wirz, Beat,Soukup, Milan
, p. 187 - 189 (1997)
An efficient enzymatic procedure for the enantio- and regioselective monohydrolysis of diethyl 2-isobutyl succinate 3 using subtilisin Carlsberg has been developed. The product (R)-2-isobutyl succinic acid 4-ethyl ester 4, a collagenase inhibitor building block, was obtained in high enantiomeric excess (> 99%) and yield (> 45%). Similarly, (R)-2-isobutyl succinic acid 4-nitrile 2 was produced in 98% ee from its ethyl ester 1.
IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN
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Page/Page column 53-54, (2011/12/02)
The present invention is directed towards synthesis of (S) - 3-cyano-5-methyl-hexanoic acid ethyl ester. A cost effective, eco-friendly process for preparation of enantiomerically pure (S)-3-cyano-5-methyl-hexanoic acid alkyl ester, intermediate of γ-amino acids, particularly (S)-pregabalin.
INHIBITORS OF ANTHRAX LETHAL FACTOR
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, (2008/06/13)
Methods, compounds and compositions for preventing and treating anthrax infections by inhibiting Anthrax Lethal Factor (LF) activity.
Hydroxamic acid based collagenase inhibitors
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, (2008/06/13)
Thid disclosure relates to a novel class of hydroxamic acid based collagenase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment
Hydroxamic acid based collagenase inhibitors
-
, (2008/06/13)
This disclosure relates to a novel class of hydroxamic acid based collagenase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment