Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.
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(2019/11/19)
Ruthenium catalyzed amination cyclization of 1,2,4-butanetriol with primary amines: A borrowing hydrogen strategy for 3-pyrrolidinol synthesis
A ruthenium based catalytic system ([Ru(p-cymene)Cl2]2/XantPhos with substoichiometric Cs2CO3) has been established to effectively achieve the first direct amination cyclization of 1,2,4-butanetriol with primary
On the phenyliodine(III)-bis(trifluoroacetate)-mediated olefin amidohydroxylation reaction
When appropriately substituted amides are treated with PIFA in a non-nudeophilic solvent like trifluoroethanol, a stable N-acylnitrenium ion is generated. If under such conditions a C=C double bond is present in the molecule, an intramolecular cyclization
Tellitu, Imanol,Urrejola, Andrea,Serna, Sonia,Moreno, Isabel,Herrero, M. Teresa,Dominguez, Esther,SanMartin, Raul,Correa, Arkaitz
p. 437 - 444
(2008/02/03)
Preparation of N-phenyl-(S)-prolinol-derived P,N-ligands and their application in Pd-catalyzed asymmetric allylic alkylation
Several NPN-type ligands bearing two chiral pyrrolidinyl groups derived from N-phenyl-(S)-prolinol were prepared by two synthetic methods. Their palladium-complex-catalyzed asymmetric allylic alkylation of malonates with 1,3-diphenyl 2-propenyl acetate delivered the products with good to high enantioselectivities (84-97% ee), including an optically active fluorine-containing compound.
Jiang, Biao,Huang, Zuo-Gang,Cheng, Ke-Jun
p. 942 - 951
(2007/10/03)
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