- A gold catalytic pinacone method of rearrangement of
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The invention provides a method used for catalytic rearrangement of pinacol with gold. A reaction general formula is disclosed in the invention, wherein R1, R2, R3, and R4 may be common alkyl, cycloalkyl, and aromatic rings. A gold catalyst needed by reac
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Paragraph 0027; 0028; 0029; 0030; 0042; 0043; 0044-0046
(2017/11/22)
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- PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS
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The invention provides a combination comprising an ancillary compound (e.g. one, two or more ancillary compounds) and a compound of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing f
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- Tandem pinacol coupling-rearrangement of aromatic aldehydes with hydrogen catalyzed by a combination of a platinum complex and a polyoxometalate
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Together with a strongly oxidizing polyoxometalate, H5PV 2Mo10O40, PtII(N-(2,6- diisopropylphenyl)pyrazin-2-ylmethanimine)Cl2 forms a combined catalyst that was active in the tandem pinacol coupling-rearrangement of aryl aldehydes to give mostly the corresponding diarylacetaldehyde in high yields using molecular hydrogen as the reducing agent. The Royal Society of Chemistry.
- Branytska, Olena,Shimon, Linda J. W.,Neumann, Ronny
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p. 3957 - 3959
(2008/10/09)
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- PHARMACEUTICAL COMPOUNDS
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The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length
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Page/Page column 98
(2010/11/25)
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- Use of tetrahydropyridine derivatives to prepare medicines for treating diseases causing demyelination
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The invention relates to the use of tetrahydropyridine derivatives of the formula in which: R1is a halogen or a CF3, (C1-C4)alkyl or (C1-C4)alkoxy group; Y is a nitrogen atom or a CH group;
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- Use of 4-substituted tetrahydropyridines for making medicines acting on TGF-β1
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The invention relates to the use of a compound of formula (I): for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-β1.
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Page column 13
(2010/02/04)
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- Electrolytic Dechlorination of DDT In a Bicontinuous Microemulsion
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Electrolytic reduction in a bicontinuous microemulsion of surfactant, oil, and water removed aliphatic and aromatic chlorines from DDT. Microemulsions of didodecyldimethylammonium bromide/dodecane/water used with graphite felt cathodes provided a less expensive, less toxic approach to DDT electrolysis compared to using conventional organic solvents and metal electrodes. Good rates of aliphatic dechlorination were achieved by applying -1 V vs. Ag/AgBr and using the catalyst Co(bpy)32+, but the best yield (34 percent in 3 hr) of the fully dechlorinated hydrocarbon 1,1-diphenylethane was achieved by using -2 V with oxygen in the reaction medium.
- Schweizer, Silvia,Rusling, James F.,Huang, Qingdong
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p. 961 - 970
(2007/10/03)
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- One-pot conversion of α-substituted arylacetaldehydes into α-dicarbonyl compounds
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α-dicarbonyl compounds 7-12 can be easily prepared by reaction of methylene chloride solutions of several α-substituted arylacetaldehydes 1-6 with a slight excess of tris-(o,p-dibromophenyl) ammoniumyl hexachloro antimonate A.
- Lopez, Luigi,Mele, Giuseppe,Nacci, Angelo,Troisi, Luigino
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p. 3897 - 3900
(2007/10/02)
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- Reduction of 2,2-Diaryl-1-nitroethylenes : New Synthesis of 2,2-Diarylacetaldehydes and 1,1,4,4-Tetraarylbuta-1,3-dienes
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2,2-Diarylacetaldehydes (VII) have been obtained by selective and controlled reduction of 2,2-diaryl-1-nitroethylenes (IV) in acid medium, and also by acid hydrolysis of 2,2-diarylvinyl-N-acetamides (VI).Nitroalkenes (IV) have been prepared by the reaction of 2,2-diarylethylenes (I) with nitrous acid whereas N-acetamide derivatives (VI) have been obtained by reductive acetylation of the nitro compounds (IV).A number of 1,1,4,4-tetraarylbuta-1,3-dienes (XI) have been obtained by the condensation of 2,2-diarylacetaldehydes (VII) with appropriate 2,2-diarylethylenes (I).Structures of the products have been assigned on the basis of analytical data and chemical and spectral evidences.
- Tadros, Wadie,Awad, Sami B.,Sakla, Alfy B.,Abdul-Malik, Nadia F.,Armanious, Emili R.
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p. 199 - 202
(2007/10/02)
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